艾滋病治疗是世界难题，能否通过疫苗来控制HIV的传播？上海科研人员近日在艾滋病病毒I型疫苗的研发上取得突破性成果，探索出新的疫苗制备方法，并首次在果蝇细胞上试验成功。

AIDS treatment is the world's problems，If I can pass the vaccine to control the spread of HIV？Shanghai scientific researchers recently in HIV vaccine development of type I get breakthrough results，Explore new vaccine preparation methods，And for the first time in fruit flies on the cells success。

　　该研究成果在国际知名杂志《病毒学杂志》在线发表。

The research achievements in the international famous magazine《Virology magazine》Published online。

　　中科院上海巴斯德研究所研究员周保罗带领的研究组找到了疫苗制备方法的突破口——被称为“空心杀手”的“病毒样颗粒”。该颗粒没有艾滋病病毒核酸，不能自主复制，但在形态上却与真正的艾滋病病毒粒子相同，如果能在进人体后让人产生相应抗体，进而使人体能对艾滋病毒免疫，那就意味着艾滋病病毒疫苗的研发取得了成功。

Of the Shanghai Pasteur institute researchers weeks Paul led the team found the vaccine preparation methods-known as the breakthrough“Hollow killer”of“Virus samples particles”。The particle no AIDS virus nucleic acid，Cannot independent copy，But in shape but with the real AIDS virus particles are the same，If can let a person produce after into human body corresponding antibody，And then can make human body to the AIDS virus immune，That means the HIV vaccine research and development a success。

　　在哪个对象上进行试验又是一道难题。周保罗选择的是果蝇，相比鼠、猴，又是一次创新。经过多年研究，终于取得良好效果。

Which object in tests is a difficult problem。Week of choice is Paul flies，Rat compared、monkey，Another innovation。After many years of research，Finally achieve good effect。

　　周保罗介绍说，用传统疫苗制备方法试验存在病毒污染、各批次不稳定、蛋白剪切难度等问题，新方法已将它们逐一克服。

Weeks Paul introduce said，With traditional vaccine preparation method test virus pollution、Each batch is not stable、Protein shear difficulty，The new method has them one by one to overcome。

　　在果蝇试验后，周保罗再以鼠、猴为对象进行验证。目前小鼠体内已产生抗体反应，下一步将在猴子身上进行“攻毒”试验。如果猴子能够产生对艾滋病毒免疫抗体，就可以为最终的人体试验的成功铺平道路。

In the fruit fly after test，Weeks Paul again with mice、Monkey for object is verified。At present already produce antibody response in mice，The next step will be in monkeys“Poison attack”test。If the monkey to produce antibodies to the AIDS virus immune，For the final human trials to pave the road of success。

　　“如果猴子试验能达到预期效果的话，接下来就做人临床试验，分一二三期，一般至少五年到十年。”周保罗说。这也就意味着，如果一切顺利的话，届时，艾滋病毒疫苗的最终问世便有了坚实的基础。(记者 冯玉婧 潘旭)

“If the monkey trial can achieve the expected effect words，Next person clinical trials，Points just a little 3 period，In general, at least five to 10 years。”Weeks Paul said。This also means，If all goes well，when，The AIDS virus vaccine was eventually will have a solid foundation。(Reporter FengYuJing PanXu)