日本庆应义塾大学和顺天堂大学的研究人员10日宣布，他们用帕金森氏症患者的皮肤细胞培养出诱导多功能干细胞(iPS细胞)，并首次再现了患者脑内出现的异常蛋白质蓄积。

Japan's keio university and ShunTianTang university researchers 10 announced,They use Parkinson's disease patients skin cells develop induced multi-function stem cells(IPS cell),For the first time and reproduce the patient brain appear abnormal protein accumulation.

　　帕金森氏症是一种中老年人常见的中枢神经系统变性疾病，主要表现为手脚震颤和身体僵硬等，并发认知障碍的概率很高。该病病因目前仍不十分清楚，一般认为病因之一是脑部分泌神经传递物质多巴胺的神经细胞减少。

Parkinson's disease is a kind of the elderly common central nervous system degenerative disease,Main show is hands and feet tremor and stiff, etc,Concurrent cognitive impairment probability is very high.The disease causes is still not very clear,General think cause brain secretion is one of neurotransmitters dopamine nerve cells to reduce.

　　研究人员用一名70多岁帕金森氏症患者的皮肤细胞，培养出了iPS细胞，并令iPS细胞分化形成神经细胞。经过分析，他们发现神经细胞内出现了与发病相关的异常蛋白质蓄积。

The researchers used a more than 70 years old patients with Parkinson's disease of the skin cells,To create the iPS cell,And make iPS cell differentiation formation of nerve cells.After analysis,They found that nerve cells appeared and the related to the abnormal protein accumulation.

　　这名患者去世后，研究人员在调查其脑部时，发现了同样的蛋白质蓄积，从而确认由iPS细胞发育成的神经细胞准确再现了患者生前脑内的情况。

The patient died,The researchers in their brain investigation when,Found the same protein accumulation,Thus confirmed by iPS cells develop into nerve cells accurate emersion the lifetime of the patient in the brain.

　　研究小组带头人、庆应义塾大学教授冈野荣之指出，帕金森氏症要经过数十年时间才会发病，而通过在试管内培养神经细胞，数周时间就能检测出疾病的征兆。

The team leader/Keio university professor hill wild glorious pointed out,Parkinson's disease to after decades time will disease,And through the in vitro culture of nerve cells,Weeks can detect signs of the disease.

　　这一发现将有助于弄清帕金森氏症的发病机制，并有助于该病的早发现和早治疗。(记者蓝建中)

The discovery will help to find out the pathogenesis of Parkinson's disease,And contribute to the early detection and early treatment.(Reporter LanJianZhong)