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中国科学家解密亚洲人群精神分裂症遗传密码--亲稳网络舆情监测室
2012-11-05

  中新网昆明11月5日电 (顾一航 张刚强)精神分裂症也会遗传?近年来,这一理论已从欧洲人群为样本的研究中得到证实。记者5日从中科院昆明动物研究所获悉,经该所科学家研究,欧洲人群精神分裂症易感基因在亚洲人群中同样存在,并与病症显著相关

Beijing on November 5, kunming (The a air tickets are strong)Schizophrenia is can genetic?In recent years,This theory has been people from Europe for sample study confirmed.Reporters from 5, the Chinese academy of sciences institute of kunming animals learn,This study by scientists,European population susceptibility genes of schizophrenia in Asia also exists in the crowd,Significant correlation with disease.

  精神分裂症是困扰人类的重大精神疾病之一,且具有非常高的遗传力。近年来,随着全基因组关联性分析的逐步开展,人们已经报道了一系列的精神分裂症易感基因。然而,这些研究大多集中在欧洲人群,所报道的易感基因在亚洲人群中是否也与精神分裂症显著相关并不清楚。

Schizophrenia is significant beset mankind one of mental illness,And it has a very high genetic force.In recent years,As the whole genome relevance analysis carried out step by step,It has been reported that a series of schizophrenia-susceptibility gene.however,These studies mostly concentrated in Europe the crowd,Reports the susceptibility genes in the crowd in Asia is significantly associated with schizophrenia is not clear.

  近日,昆明动物研究所宿兵实验室与新加坡基因组研究所、日本藤田保健衛生大学合作,结合采集自云南玉溪和昆明的样本,对6565份亚洲病例-对照样本进行了分析,目的基因为前期欧洲人群中发现的与精神分裂症显著相关的基因VRK2、rs2312147。

recently,Kunming institute of animal SuBing lab and Singapore genome research institute/Japan rattan field health health university cooperation,Combined with acquisition from yunnan yuxi and kunming sample,In 6565 a Asian case-control sample were analyzed,Purpose gene for the European people with schizophrenia found significant related gene VRK2/rs2312147.

  初步分析结果发现,精神分裂症显著相关基因rs2312147在亚洲人群中与精神分裂症强烈相关。随后,研究人员增加了来自美国国立精神卫生研究院等的欧洲人群的病例对照样本,并发现相关性增强。

Preliminary analysis results,Schizophrenia was significantly associated rs2312147 genes in Asia the crowd and schizophrenia strong correlation.then,The researchers added from the national institute of mental health, such as the European case control sample,And found correlation enhancement.

  “这些证据很好地支持了前期全基因组关联性分析的发现。”昆明动物所研究员宿兵实验室博士生李明表示,研究发现精神分裂症相关基因VRK2在精神分裂症患者血液中mRNA表达相对正常人明显升高,进一步支持了相关性分析的结果,同时证实了VRK2在中国人群中也是精神分裂症易感基因。(完)

"The evidence is very good to support the whole genome the relevance analysis found."Kunming animal researchers SuBing laboratory doctoral student li Ming said,The study found that schizophrenia VRK2 related gene in patients with schizophrenia mRNA expression in the blood relative normal increased significantly,Further support to the correlation analysis results,At the same time VRK2 confirmed in China is also the crowd schizophrenia-susceptibility gene.(finish)


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