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日本利用iPS细胞再现癫痫病理--亲稳网络舆情监测室
2013-05-07

  日本研究人员2日在新一期英国期刊《脑分子》上报告说,他们通过癫痫患者的皮肤细胞培养出诱导多功能细胞(iPS细胞),并成功再现癫痫发病机理。

Researchers in Japan 2 days in the new issue of the journal[Molecules in the brain]The report said,Their skin cells to produce by people with epilepsy induced pluripotent stem cells(IPS cells),And successfully reproduce the pathogenesis of epilepsy.

  癫痫是大脑神经元突发性异常放电,导致大脑功能短暂障碍的一种慢性病。日本福冈大学和庆应义塾大学的研究人员,征集患有严重肌肉阵挛性癫痫的婴儿,利用其皮肤细胞培育出iPS细胞,并诱导培育出多种神经细胞。

Epilepsy is a sudden abnormal discharge of brain neurons,Lead to brain function brief obstacle to a chronic disease.Fukuoka, Japan, researchers at keio university and the university,For babies with severe myoclonic epilepsy,Use their skin cells produced iPS cells,Induction and produced a variety of nerve cells.

  研究人员通过检测这些神经细胞的电信号发现,负责抑制脑内电活动的神经细胞功能降低,这确认了部分癫痫由抑制大脑神经元电活动的细胞功能降低所致。

The researchers found by measuring the electrical signals of nerve cells,Responsible for the inhibition of brain function of electrical activity of neural cells is reduced,This confirms that the partial epilepsy by inhibiting cell function of electrical activity in the brain neurons caused by reducing.

  此前,已有研究人员利用阿尔茨海默氏症患者和肌肉萎缩症患者的皮肤细胞,制作出iPS细胞,并在实验室里再现这两种疾病的病理。日本研究人员希望利用上述新研究成果,彻底了解癫痫的发病机制,为开发新疗法提供依据。(记者蓝建中)据新华社

after,For researchers to use in patients with alzheimer's disease and skin cells from patients with muscular dystrophy,Create iPS cells,And reproduced in the laboratory of these two diseases pathology.Japanese researchers hope to use the new research results,Thorough understanding of the pathogenesis of epilepsy,Provide a basis for the development of new treatments.(The reporter LanJianZhong)According to the xinhua news agency


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