我国科学家在中国人群中找到了一个新的胸主动脉瘤致病基因SMAD3，这意味着对这些胸主动脉瘤患者而言，手术治疗将不再是唯一途径，药物治疗将成为可能。

我国科学家在中国人群中找到了一个新的胸主动脉瘤致病基因SMAD3,This means that for the patients with thoracic aortic aneurysms,Surgery will no longer be the only way,Medication will be possible.

　　胸主动脉是心脏最主要的“输油管”，输注由心脏泵出的血液到身体各大器官。胸主动脉瘤是主动脉局部向外膨出形成的瘤样结构。

胸主动脉是心脏最主要的"pipeline",Infusion by the heart pump blood to the body's major organs.Thoracic aortic aneurysms is aortic tumor sample structure of local bulging outward form.

　　随着不断病理性扩张，动脉壁不断变薄，如不能及时有效预防和治疗，动脉壁破裂会导致致命的大出血，这是猝死的主要原因之一，抢救成功率几乎为零。

随着不断病理性扩张,Arterial wall thinning,Such as not timely and effective prevention and treatment,Arterial wall rupture can lead to fatal bleeding,This is one of the leading causes of death,The rescue success rate is almost zero.

　　研究发现，由于SMAD3基因的改变，引起炎症细胞特性的改变，导致主动脉扩张，从而引发动脉瘤。小鼠实验表明，通过干预炎症因子GM-CSF，可明显抑制动脉瘤的发生和动脉瘤的破裂。

研究发现,Because the change SMAD3 gene,A change of inflammatory cells characteristics,Lead to aortic dilatation,Triggering the aneurysm.Experiments show that in mice,By intervening in the inflammation factor gm-csf,Can obviously inhibit the occurrence and aneurysm rupture of aneurysm.

　　主持这项研究的武汉中心医院院长、教授夏家红介绍，胸主动脉瘤新的致病基因的发现，将成为其可能的治疗靶点。同时进行的小鼠实验也证实，通过基因药物对这种胸主动脉瘤预防和逆转是可行的。(据新华网)

主持这项研究的武汉中心医院院长/Professor kuznetsov sa is introduced,Thoracic aortic aneurysms found new disease genes,Would be a possible therapeutic targets.Also confirmed in mice,Through gene drugs for the prevention and reversal of thoracic aortic aneurysms is feasible.(According to xinhua)