中新网合肥9月14日电(杨保国 吴兰)记者14日从中国科技大学获悉，该校生命科学学院温龙平教授研究组发现一种短肽，该物质能够在治疗癌症等重大疾病中屏蔽正常细胞中毒的不利可能，为癌症治疗提供新思路和方法。

Hefei local fars news agency reported on September 14 dec(YangBaoGuo WuLan)Reporters from 14 of university of science and technology of China,The college of life science LongPing temperature professor the team found that a short peptide,This material can in the treatment of cancer and other major diseases shielding normal cells poisoning adverse may,For cancer therapy provide new ideas and methods.

　　据悉，研究组最新发现的短肽，能够调控稀土纳米材料所导致的细胞自噬行为，从而大大降低纳米材料的毒副作用，不仅能提高对肿瘤细胞的杀伤效应，还能屏蔽正常细胞中毒死亡的可能。

It is reported,The newly discovered short peptide,Can control of rare earth nanomaterials in cell autophagic behavior,So as to greatly reduce the side effects of nanometer materials,Can not only improve the tumor cells to kill effect,Still can shield the normal cell poisoning death of may.

　　细胞自噬是细胞利用溶酶体降解受损的细胞器、大分子物质和长寿命蛋白质以维护细胞自稳态的关键细胞生物学过程，与多种重大疾病的发生、发展及治疗息息相关，目前该项研究已成为继细胞凋亡之后又一迅猛发展的生物学研究领域。

Cell autophagy is the cell USES lysosome degradation damaged organelles/Macromolecule material and long life protein in order to maintain cell homoeostasis key cell biological process,And a variety of major disease/Development and treatment is closely linked,At present the study has become the cell apoptosis and after the rapid development of biology research field.

　　近年来的研究表明，吸入和以诊疗为目的进入体内的许多纳米颗粒，可引发细胞自噬并促进细胞死亡。这种纳米颗粒引发的细胞自噬，一方面在特定细胞中可用于帮助疾病治疗，如增强癌症的放化疗和免疫治疗效果，治疗神经退行性疾病(如帕金森病等)，另一方面在正常细胞中会引发毒性，需要加以规避。因此有效地调控纳米颗粒引发的自噬效应，对纳米材料及纳米器件的体内应用将起到巨大的促进作用。

Recent research shows that,Suction and the diagnosis and treatment for the purpose to enter many nanoparticles,Can cause cell autophagy and promote cell death.This kind of nanoparticles trigger cell autophagy,On the one hand in specific cells can be used to help treatment of the disease,Such as increased cancer chemotherapy and immunotherapy effect,Treatment of neurodegenerative diseases(Such as Parkinson's disease, etc),On the other hand in normal cells can cause toxicity,Need to avoid.So effective regulation nanoparticles triggered autophagic effect,Of nanometer materials and nano device body application will play a great role in promoting.

　　研究小组此次发现的一种短肽RE-1，通过小鼠实验表明，该短肽能够通过抑制纳米颗粒与细胞的相互作用以降低细胞自噬水平，从而屏蔽由于细胞自噬而导致的细胞毒性和组织损伤，提高纳米材料的生物安全性。另一方面，该短肽与能够识别肿瘤的短肽RGD组成的复合肽，通过与肿瘤细胞外的整合素相互作用，而提高稀土纳米材料在肿瘤细胞中的自噬及杀伤效应。因此，该发现有望同时实现在正常细胞中屏蔽自噬和在肿瘤细胞中提高自噬以增进化疗的目标。

The research team found a short peptide RE - 1,Through the mouse experiments show that,This short peptide can inhibit nanoparticles and cell interaction in order to reduce cell autophagic level,Thus shielding because the cells autophagy in cell toxicity and tissue damage,Improve the nano materials of biological safety.On the other hand,This short peptide and able to identify tumor short RGD peptides composed of composite peptide,Through the and tumor extracellular integrin interaction,And improve the rare earth nanometer materials in tumor cells of autophagy and kill effect.therefore,It is hoped that the discovery will also achieve in normal cells shielding autophagy in tumor cells and improve autophagy to promote the goal of chemotherapy.

　　目前，相关论文近日在线发表在国际著名学术期刊《自然-材料》上，其中，新加坡国立大学等科研人员参与了部分实验工作。(完)

At present,The relevant papers recently published online in the international famous academic journal[Natural - material]on,the,National university of Singapore and scientific research personnel took part in some of the experimental work.(finish)