中新社东京10月5日电 (记者 谢国桥)日本京都大学研究团队5日在美国《科学》杂志电子版上发表论文，宣布其成功从老鼠的iPS细胞(人工诱导性多能干细胞)中培育出卵子，并使其体外受精后产下健康后代。专家表示，这一成果标志着不孕不育研究取得重大进展。

China news agency on October 5, Tokyo (Reporter XieGuoQiao)Japan's Kyoto university research team 5, in the United States[science]Electronic magazine published papers,Announced its successful from rat iPS cell(Artificial induced pluripotent stem cells)Developed eggs,And make its in vitro fertilization gave birth to healthy offspring after.Experts say,This achievement marked the sterility has made great progress in study.

　　据了解，研究小组先从雌鼠iPS細胞中制造出原始生殖细胞，把它与将成为卵巢的体细胞一起培养后，植入雌鼠卵巢内，生成了卵子，然后将卵子取出进行体外受精，再将受精卵植入雌鼠体内，结果雌鼠产出健康后代。该小组用ES细胞(胚胎干细胞)进行了同样的实验，得到了同样的结果。

It is understood,The team from the first female iPS cells create original reproductive cells,Take it and will become ovarian cells after training together,Female implanted in the ovary,Generated the eggs,Then remove eggs for in vitro fertilization,Then fertilized egg implanted in females,Results pheromones output healthy offspring.The team with ES cells(Embryonic stem cells)In the same experiment,Got the same result.

　　研究小组称，通过观察iPS细胞变为卵子的过程，可以了解卵子在体内生成的机制，从而查明不孕不育的原因。该研究小组去年成功从老鼠的iPS细胞中制造出具有生殖功能的精子。如这两个研究成果能用于人类，则可通过人体的皮肤细胞制造出iPS细胞，再用iPS细胞制造出的精子和卵子进行体外受精，使无法产生精子或卵子的夫妻获得继承自身遗传基因的孩子。研究小组成员之一的齐藤通纪教授说，希望“成果能有助于不孕不育治疗”。京都大学iPS细胞研究所所长山中伸弥表示，研究成果“使不孕不育原因的查明和新药研发迈出了一大步”。

The team says,Through the observation of iPS cell into the process of eggs,Can understand eggs in the body formation mechanism,So as to find out the cause of infertility.The team success last year from rat iPS cells create a reproductive function sperm.If the two research results can be used to human,Can be through human skin cells produce iPS cell,Garnish with iPS cells produce sperm and ovum for in vitro fertilization,That cannot produce sperm or eggs for the husband and wife inherit their own genetic children.Research group one of the members of the general age pp.24-25 professor said,hope"Results can help infertility treatment".Kyoto university iPS cell institute director in the mountains stretch "said,Research results"Make sterility reason find out and new drug research and development have made an important step forward".

　　但也有专家指出，人类和老鼠的iPS细胞性质不同，很难用与老鼠同样的方法从人体制造原始生殖细胞。在制造iPS细胞时，还有可能损伤遗传基因。此外，人工制造卵子还存在伦理方面的问题。

But there are also experts say,The human and mouse iPS cell to the different properties,It is difficult to use the same method and the mouse from human manufacturing primitive germ cell.In manufacturing iPS cells,And may damage the genetic gene.In addition,Artificial manufacturing eggs there are the ethical problems.

　　iPS细胞由京都大学教授山中伸弥2006年首先研制成功，具有生成各种组织、器官细胞的能力，在利用干细胞来修复人体器官或组织的尖端医学技术——再生医疗领域具有广泛应用前景，近年来颇为世界所瞩目。日本在该方面研究处于世界领先地位。(完)

IPS cell by the Kyoto university professor in the mountains stretch for 2006 first successfully developed,Have to create all kinds of organizations/The ability of organ cells,In the use of stem cells to repair the human organ or organization of the advanced medical technology, regenerative medical fields have extensive application prospect,In recent years rather world attention.Japan in this research a leading position in the world.(finish)