中国科学家在探索艾滋病疫苗道路上又迈出一步，攻克了以腺病毒为载体的艾滋病疫苗受抗体阻碍难题。此类疫苗因为腺病毒载体易被抗体中和而难以发挥效用。

Chinese scientists explore in AIDS vaccine road and take a step,Conquer the adenovirus as the carrier of AIDS vaccine by antibody block problem.This kind of vaccine for adenovirus vector are easily antibody neutralization and difficult to play to utility.

　　中国科学院广州生物医药与健康研究院研究人员在恒河猴模型上进行了腺病毒载体艾滋病疫苗试验。该试验没有将疫苗直接注入体内，而是将体内某类细胞(外周血单细胞)分离出来，与腺病毒载体艾滋病疫苗进行体外感染，再回输到体内，由于体内血液中的中和抗体无法识别已进入细胞内的疫苗，疫苗便可以在体内发挥作用。

The Chinese academy of sciences guangzhou biological medicine and health research institute researchers in rhesus monkeys model adenovirus vector AIDS vaccine trial.This test will be no vaccine are injected into the body,But will the body a type of cell(Peripheral blood cell)separated,And adenovirus vector AIDS vaccine for in vitro infection,Then feedback to the body,Due to the body in the blood of the neutralizing antibody cannot identify has entered the cell vaccine,Vaccine can play a role in the body.

　　项目负责人陈凌博士和孙彩军博士28日接受采访时介绍，此项目得到“十二五”国家科技重大专项经费支持。这是继今年8月科技重大专项艾滋病疫苗II期临床试验启动后，中国艾滋病疫苗研究领域又一项有益探索。

Project leader dr professor Chen ling and SunCaiJun doctor 28 interviews is introduced,The project has"1025"National science and technology major special funds to support.This is the August science and technology major special AIDS vaccine phase II clinical trial after the start,China AIDS vaccine research field and a helpful exploration.

　　腺病毒是人体经常感染的一种常见呼吸道病毒，很多感冒都是由感染腺病毒引起的。腺病毒广泛应用于各类疫苗中，用做艾滋病疫苗载体是因为它能刺激产生对HIV病毒最具攻击力的细胞，被认为是提高细胞免疫能力最有效的病毒。

Adenovirus is human body often infected a common respiratory virus,A lot of colds are made by infection gland caused by virus.Adenoviruses are widely used in all kinds of vaccine,Used as AIDS vaccine carrier because it can activate the HIV virus to the most damage cells,Is considered to be the most effective to improve cell immunity ability of the virus.

　　2007年9月，全球瞩目的美国默克公司艾滋病疫苗临床II期试验宣告失败。这项同样以腺病毒为载体的抗艾疫苗当时被看作是艾滋病研究史上最先进、最有前途的候选疫苗。其中腺病毒载体被抗体中和是导致试验失败的原因之一。

In September of 2007,Global attention of American Merck AIDS vaccine clinical phase II test failed.The same in order to adenovirus as the carrier of the resistance to ai vaccine was regarded as the most advanced HIV/AIDS research history/The most promising candidate vaccine.The adenovirus vector was antibody and lead to test is one of the reasons why he failed.

　　孙彩军说：“腺病毒大部分人小时候都感染过，感染过之后人体内会产生针对性抗体，当我们再次应用以腺病毒为载体的疫苗时，抗体就会把腺病毒中和掉，使得这些疫苗不能发挥作用。”而此次中国艾滋病疫苗研究的新突破初步修正了这一问题。

SunCaiJun said:"Adenovirus most people have childhood infection,After infected human body can produce specific antibody,When we used again with adenovirus as the carrier of the vaccine,Antibody will take adenovirus neutralization off,Make the vaccine can't play a role."And the Chinese AIDS vaccine research new breakthrough preliminary fixed the problem.

　　孙彩军介绍，目前这项研究在动物实验中取得良好效果，正在筹备进入一期临床试验阶段。相关研究成果已发表于国际期刊《病毒学杂志》上。

SunCaiJun introduced,At present the research in animal experiments have gained good effects,Are preparing to enter a phase of clinical test.Related research results have been published in international journals[Virology journal]on.

　　中国艾滋病疫苗联盟副主任委员，清华大学艾滋病综合研究中心张林琦教授认为这次成功去除血液腺病毒中和抗体阻碍的实验是艾滋病疫苗研究的一次有益尝试。这是中国结合世界先进经验，进行自主创新研发的成果。

China AIDS vaccine, deputy director of the league members,Tsinghua university AIDS comprehensive research center ZhangLinQi professors think that this success to remove blood adenovirus neutralizing antibody hinder experimental AIDS vaccine research is a beneficial attempt.This is a Chinese combined with the world's advanced experience,For independent innovation research and development results.

　　中国进行艾滋病疫苗研究起步比较晚，但近年来发展成果显著。国家“十一五”和“十二五”规划都将艾滋病防治纳入国家科技重大专项。政府针对艾滋病疫苗研究的投入力度也不断增大。孙彩军认为，国家对艾滋病疫苗研究的大力投入体现了政府对艾滋病防治问题的重视。

China AIDS vaccine research started quite late,But in recent years the development of remarkable achievements.countries"11th five-year plan"and"1025"Planning will be HIV/AIDS prevention and control into the national science and technology major projects.The government is AIDS vaccine research investment is also increasing.SunCaiJun think,Country of AIDS vaccine research vigorously investment, shows that the government would pay more attention to prevention and control of HIV/AIDS problem.

　　中国还有其他艾滋病疫苗自主研发项目。据张林琦介绍，目前这些项目中走在前端的便是复制型痘病毒载体艾滋病疫苗。

China and other AIDS vaccine independent research and development project.According to ZhangLinQi introduced,At present, these projects walking in front is copy type pox virus carrier AIDS vaccine.

　　该疫苗由中国疾病控制与预防中心艾滋病首席专家邵一鸣带领的课题组研制开发，以曾对消灭天花疫情做出巨大贡献的天坛株痘苗病毒为载体。该疫苗已完成I期临床试验，检验了其良好的安全性。今年8月，该疫苗正式启动II期临床试验，对疫苗的有效性进行验证。目前，已有31名受试者接受第一针注射，受试结果将于2014年揭晓。

The vaccine by the China disease control and prevention center chief expert AIDS ShaoYiMing lead group research and development,To eradicate smallpox outbreaks have made great contribution to the temple of heaven plant vaccine virus as the carrier.The vaccine has completed phase I clinical trials,Test the good security.August,The vaccine official start phase II clinical trials,To verify the effectiveness of the vaccine.At present,With 31 patients to accept the first needle injection,The tested results will be announced in 2014.

　　中国卫生部最新数据显示，截至2012年10月底，全国累计报告艾滋病病毒感染者和病人492191例，其中2012年新报告68802例，艾滋病死亡人数为17740例，较去年同期增加8.6%。(田颖李一凡)

China's ministry of health has the latest data display,By the end of October 2012,The accumulated report of AIDS virus infection and 492191 patients,The new report 68802 cases in 2012,AIDS death toll for 17740 cases,Compared to the same period last year increased by 8.6%.(TianYing LiYiFan)