牙齿一戳就碎 近亲基因惹祸？ Teeth a stamp is broken relatives gene to bring calamity?

　　年仅21岁的湖南女生小雪(化名)多年来一直不敢张口大笑。“别人都取笑我像个瘪嘴的老太太，心理上一直感到自卑。”小雪说，从12岁开始，牙齿逐渐发黄发黑变烂，发烂的小洞逐渐变大，用牙签一挑就碎成粉。如今，她满口牙齿几乎掉光，只剩下4颗牙齿。然而，这仅存的4颗牙齿也开始发黄变烂，即将步其它牙齿后尘。

Only 21 years old of hunan girl light snow(The allotted time periods specified by the)For many years, always can't open."The other people all make fun of me like a nutcracker old lady,The psychological always feel inferior."Light snow said,From the age of 12,Teeth are yellow black become rotten,The small hole that 发烂 gradually become larger,Carry it with a toothpick crushed into a powder.now,Her mouth teeth almost off the light,Only have four teeth.However,,The remaining four teeth also started to get yellow,Will follow other teeth's.

先天性恒牙缺失 Congenital permanent teeth missing

　　经X光片检查，小雪的口中除了3颗智齿是恒牙，其他剩下的牙齿或牙根都是乳牙。接诊医生认为，小雪牙齿无故发烂脱落的是乳牙，这种疾病属于先天性恒牙缺失，“小雪父母是表兄妹，她的情况很有可能是近亲联姻所致。”

By the X-ray inspection,The mouth of the light snow except 3 wisdom tooth is permanent teeth,The rest of the other teeth or root are baby teeth.Accepts the doctor think,Light snow teeth without 发烂 fall off of the teeth,The disease belongs to congenital permanent teeth missing,"Light snow parents are Cousins,Her condition is likely is caused close kin."

　　为此，记者咨询广东省口腔医院副院长黄少宏。他表示，先天性恒牙缺失未必和近亲联姻有关。因为先天性疾病不一定是遗传所引起的，有可能是基因突变。

For this,Reporter advisory HuangShaoHong, vice President of the oral cavity hospital of guangdong province.He said,Congenital permanent teeth missing is not necessarily associated with close kin.Because congenital diseases is not often,May be genetic mutations.

12岁起乳牙发烂 12 years old baby teeth 发烂

　　小雪称，她来湖南邵阳农村地区，目前在白云区打工。小雪说，她的牙齿一直比较小而且有点黄，到12岁时，她的牙齿突然起变化。“本来只是一颗牙开始发黄，接着就发黑，然后发烂成一个小洞，小洞逐渐变大。我把牙签塞到洞里面一挑，牙齿就碎了，成粉了。”小雪说，刚开始只是一颗牙这样，后来慢慢扩展至整口牙，牙齿一颗颗相继发烂、碎掉。“以前每天刷牙3次，后来不能刷牙不敢用力刷，只能用盐水漱口。”

Light snow said,She came to rural areas of shaoyang, hunan province,Work is currently in the middle.Light snow said,Her teeth have been smaller and a little yellow,By the age of 12,Her teeth suddenly changes."Originally just a tooth to yellow,Then dark,Then 发烂 into a small hole,Small hole is bigger.I put the toothpick into hole inside a pick,Teeth is broken,Into powder.."Light snow said,Just beginning a tooth,Then gradually extended to the whole mouth of teeth,Successively 发烂 strong teeth/Break off."Used to brush your teeth three times a day,Later can't brush my teeth can't hard brush,Can only use brine rinse your mouth."

　　从12岁牙齿开始脱落至今，小雪缺牙已有9年时间。小雪说，这9年来，她只能吃一些面条、粥以及非常软的饭，“白菜也会吃一点，能用下面这颗大牙咬一下，但上面的大牙没有了，吃起来很费劲。肉是打成肉沫吃的，很多东西都要弄成很碎很碎才能吃。没有牙的地方就用牙龈磨着吃，所以牙龈会经常发炎。”

From the age of 12 teeth begin to fall off,Light snow lack teeth for 9 years.Light snow said,In the nine years,She can only eat some noodles/Rice porridge and very soft,"Cabbage can also eat a little,Use it under the great bite,But the fangs of the above,It's painful to eat.Meat is into foam meat to eat,A lot of things to get into is broken is broken to eat.Where no teeth grinding with gum to eat,Inflammation of the gums often so."

　　近日，小雪来到广州天河北路某医院就诊。为小雪进行检查的周显峰医生说，小雪这种罕见病例为先天性恒牙缺失。小雪虽然勉强将食物吞进肚内，但大部分食物由于没有碾磨细，依然无法在肠胃中完成正常的消化程序，导致营养成分无法被身体吸收。

recently,Light snow days hebei address hospital came to guangzhou.To check the light snow ZhouXianFeng said the doctor,Light snow this rare case of congenital permanent teeth missing.Light snow though forced to swallow the food into stomach inside,But most of the food since there is no ground,Still not finish the normal digestion process in the intestines and stomach,Lead to nutrients cannot be absorbed by the body.

　　周医生表示，由于小雪牙齿缺失时间比较长，部分牙龈已经开始萎缩，手术难度会比较大。医院准备通过种植牙手术复原牙齿，为小雪种植14颗牙齿。

Weeks, the doctor said,Due to the loss of light snow teeth longer time,Part of the gum has started to shrink,Operation will be difficult.Hospital preparation by dental implant surgery recovery teeth,For light snow planting and teeth.

近亲中无“碎牙”者 Close relatives have no"Break the teeth"the

　　小雪提到，她12岁在湖南多家口腔医院作检查，“当时医生说不好处理，等到18岁牙齿定型以后再作处理”。小雪说：“当时医生说是我爸妈近亲结婚所导致的。我妈妈叫我爷爷作舅舅，我爸喊我外婆作姑姑，他们是表兄妹。”

Light snow mentioned,She more than 12 years in hunan oral hospital for check,"Then the doctor said is not good,Wait for 18 years old teeth shape for later processing".Light snow said:"At that time the doctor said my parents as a result of marriage between first Cousins.My mother call me grandpa as uncle,My dad shouted me grandmother for aunt,They are Cousins."

　　周医生推断，像小雪这种罕见牙齿疾病则很有可能是隐性致病基因纯和所致。表兄妹结婚，是较常见的近亲结婚。据了解，大多数国家都不鼓励近亲结婚，甚至禁止近亲结婚。近亲结婚后代的死亡率高，并常出现痴呆、畸形儿和遗传病患者。这是由于近亲结婚的夫妇，从共同祖先获得了较多的相同基因，容易使对生存不利的隐性有害基因在后代中相遇(即纯合)，因而容易出生素质低劣的孩子。

Weeks, the doctor that,Like a light snow this kind of disease is very rare teeth have may be caused by pure and recessive genes.Cousins married,Is the more common close relatives get married.It is understood,Most countries are not encouraged relatives get married,Even relatives get married.Cousins married offspring of the high mortality rate,And often in dementia/Freak and genetic disease patients.This is due to close relatives married couples,From the common ancestor got more of the same gene,Easy to make harmful to the survival of recessive genes to meet in the offspring(The homozygous),So easy was born children of inferior quality.

　　小雪表示，除了“碎牙”，她的身体状态并无异常。据小雪透露，她有一个哥哥，但牙齿情况良好，并没有出现像她这样的“碎牙”情况。小雪的父母辈及祖父母、外祖父母辈中并无有牙齿病患之人。(记者莫冠婷 通讯员谭俊科、张璐妮)

Light snow said,In addition to"Break the teeth",Her body there is no abnormal condition.The light snow said,She has a brother,But the teeth in good condition,Did not appear like her"Break the teeth"situation.Light snow of the parents and grandparents/The grandparents there no teeth in patients.(The reporter MoGuanTing correspondent TanJunKe/ZhangLuNi)