中国研究人员2日在美国《科学》杂志网络版上报告说，他们将H5N1型禽流感病毒和2009年引发流感大流行的甲型H1N1流感病毒结合，发现重组后的某些病毒具备在哺乳动物间传播的能力。这项研究对遏制H5N1病毒的流行具有重要意义。

中国研究人员2日在美国[science]Magazine's online edition report said,They will the H5N1 avian influenza virus and trigger a pandemic influenza a (H1N1) 2009 virus,Found after the restructuring of some viruses have the ability to spread between mammals.The study is to contain the H5N1 virus is of great significance.

　　科学家此前已经知道，当两个病毒共同感染一个宿主时，容易发生基因片段的互换，也就是所谓的基因重配。历史上，两种不同流感病毒的基因重配造成了多次全球流感大流行，包括2009年的甲型H1N1流感等。

science家此前已经知道,When two virus to infect a host,Easy to swap genes,The so-called genetic reassortment.In the history,Two different genetic reassortment of influenza virus has caused many global flu pandemic,包括2009年的甲型H1N1流感, etc..

　　目前，在自然界中尚未检测到H5N1病毒和甲型H1N1病毒之间有基因重配。为此，中国农科院哈尔滨兽医研究所国家禽流感参考实验室主任陈化兰及其同事调查了两种病毒发生基因重配的可能性以及传播能力。

目前,Has not yet been detected the H5N1 virus in nature and has genetic reassortment between the a (H1N1) virus.To do this,Academy of agricultural sciences' Harbin veterinary research institute of China national avian influenza reference laboratory director Chen and colleagues examined the possibility of genetic reassortment two viruses and transmission capacity.

　　陈化兰在接受新华社记者采访时说，之所以选择甲型H1N1病毒，是因为它目前在许多地方依然流行，在猪身上也容易检测到这种病毒，因此H5N1病毒与甲型H1N1病毒在自然界碰到的“机会很多”，碰到后就有可能发生基因重配，虽然这一过程在自然界中可能相当缓慢。

陈化兰在接受新华社记者采访时说,Chose the a (H1N1) virus,Because it is still popular in many places,Also easy to detect the virus in pigs,Therefore the H5N1 virus and the met of the a (H1N1) virus in nature"Many opportunities",Encounter can occur after genetic reassortment,Although the process may be quite slow in the nature.

　　研究人员利用H5N1病毒和甲型H1N1病毒，在实验室里构建了含有H5N1病毒HA基因的127种病毒，然后利用小鼠测试了这些病毒的致病率，又利用另一种实验动物豚鼠来评估它们的传播能力。结果发现，“不仅仅是某一种基因的组合，而是有几种基因的组合都非常容易让H5N1病毒获得通过空气传播的能力。”比较好的一点是，这些可传播的病毒对豚鼠来讲都不致命。

研究人员利用H5N1病毒和甲型H1N1病毒,Built in the laboratory 127 viruses containing H5N1 HA gene,Then using mice tested the virus pathogenic rate,Again using another kind of experimental animal guinea pigs to evaluate their ability to spread.The results found that,"Not only is a kind of combination of genes,But there are several combinations of genes is very easy to get the H5N1 virus spreads through the air."Better it is,These can be the spread of the virus for guinea pigs are not fatal.

　　陈化兰解释说，他们的研究表明，H5N1病毒一旦获得甲型H1N1病毒的PA基因或者NS基因，它就会具备在哺乳动物之间传播的能力。这意味着该病毒将来有可能具有人际间的传播能力。

陈化兰解释说,Their research shows,The H5N1 virus once get the a (H1N1) virus of PA gene or NS gene,It will have the capacity to spread between mammals.This means that the virus could have interpersonal communication ability in the future.

　　过去两年中，对于H5N1病毒传播能力的研究曾引起巨大争议，并曾一度暂停。今年1月，鉴于“自然界的确存在这样的风险，即出现能在哺乳动物中传播的H5N1病毒”，包括陈化兰在内的全球40名相关科学家发表公开信，宣布重新启动相关研究工作。(记者 林小春)

过去两年中,H5N1 virus transmission capacity for research has caused great controversy,And had been suspended.In January of this year,In view of the"Indeed there is risk in nature,That can appear in mammals the spread of the H5N1 virus",Global 40 scientists involved, including Chen, published an open letter,Announced to restart the related research work.(The reporter Lin Xiaochun)