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武汉大学学者研究3年发现抗艾滋病毒感染新细胞--亲稳舆论引导监测室
2012-09-14

   昨日,记者从武汉大学获悉,该校学者发现一种名为“表达CD56分子的T淋巴细胞具有艾滋病毒感染的作用。该成果已于上月在国际著名学术刊物《淋巴细胞生物学》上发表。

yesterday,Reporter learned from the wuhan university,The researchers found that the school called"Express CD56 molecular T lymphocyte"It can resist the effect of HIV infection.The results have been last month in the international famous academic publications[T cell biology]Published on.

  这种细胞既具有自然杀伤的功能,又能起到自我保护的功能,是人类天然免疫系统的一个重要的组成部分,在外周血单核细胞中占5%至15%,而肠道和肝脏中的50%免疫细胞都是它。但以前的研究只发现它在抗肿瘤和抗肝炎病毒感染中起到作用,未发现其对抗艾滋病毒感染有较强作用。

This kind of cell has both the function of natural killer,And can play the function of self protection,Is the human natural immune system an important part,In the peripheral blood mononuclear cells 5% to 15%,And 50% of intestinal and liver immune cells are it.But previous research only find it on antitumor and anti hepatitis virus infection plays a role,Not found the fight against HIV infection have a stronger role.

  武大基础医学院侯炜教授与该校动物实验中心霍文哲教授团队合作研究,历经3年多时间,首次发现这种细胞培养液中的分泌物可以抑制艾滋病毒的感染和复制,并且具有广谱性,既可抑制实验室保存的艾滋病毒株,也可抑制临床上分离得到的艾滋病毒株。

Wu3 da4 HouHui based medical school professor and the animal experiment center HuoWenZhe professor team cooperative research,After more than three years time,For the first time found that the cell culture solution of secretion can inhibit infection with the AIDS virus and copy,And have a broad spectrum of sex,Can inhibit laboratory save AIDS strain,Also can inhibit clinically separation get AIDS strain.

  在研究该细胞培养液中的分泌物抑制艾滋病毒效应的机制过程中,科研人员发现,虽然分泌物对艾滋病毒进入细胞的协同受体影响甚微,但是可增强干扰素调节因子的作用,从而引起巨噬细胞发挥作用,“抗击”艾滋病毒。此外,该细胞具有增强一种新发现的抗艾滋病毒的细胞因子的作用。(湖北日报讯记者韩晓玲、通讯员蒋明)

In the study the cell culture solution of secretions inhibition the AIDS virus effect in the process of the mechanism,Researchers found that,Although the secretion of the AIDS virus into the cells' cooperative receptor has little effect,But can enhance the effect of interferon regulatory factor,Thus cause macrophages play a role,"fight"HIV.In addition,The cell can increase a new discovery of anti-hiv cytokine role.(Hubei daily reporter HanXiaoLing/Correspondent JiangMing)


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