中新网北京10月27日电 (记者 欧阳开宇)医学专家们27日在北京呼吁关注E抗原血清学转换在慢性乙肝患者抗病毒治疗过程中的作用。

Beijing on October 27 - Beijing (Reporter OuYangKaiYu)Medical experts in Beijing 27 calling attention E antigen serology conversion in patients with chronic hepatitis b antiviral treatment process function.

　　中华医学会传染病学分会副主任委员王贵强在此间举办的乙肝治疗学术活动上说，《慢性乙型肝炎防治指南》指出，一般人群乙肝表面抗原携带率为7.18%。罹患慢性乙型肝炎，如果不进行规范的抗病毒治疗，最终将可能发展为肝硬化和肝癌。

The Chinese medical association epidemiology branch committee, deputy director of the WangGuiJiang here in a hepatitis b treatment on academic activities,[Chronic hepatitis b prevention and control guide]Pointed out that,In the general population antigen of second liver surface carrying rate was 7.18%.Suffering from chronic hepatitis b,If not for standard arv treatment,Will likely to develop liver cirrhosis and liver cancer.

　　台湾大学医院肝炎研究中心主任高嘉宏介绍说，台湾学者曾进行了一项对30-65岁男性慢性乙肝患者的前瞻性随访研究，平均随访时间为8.5年，研究发现，“大三阳”患者发生肝癌的几率要比“小三阳”患者大6-7倍。

Taiwan university hospital hepatitis research center director GaoJiaHong said,Taiwan scholars held a 30 - to 65 - year - old male patients with chronic hepatitis b prospective follow-up study,During a mean follow-up of 8.5 years,The study found that,"Big 3 this world"In patients with liver cancer than chance"Small 3 this world"Patients big 6-7 times.

　　“大三阳”和“小三阳”是患者对慢性乙肝感染状态的两种俗称。常规的乙肝检测中有五项乙肝标志物检测，即“乙肝两对半”，它们依次是乙肝表面抗原，乙肝表面抗体、乙肝E抗原、乙肝E抗体、乙肝核心抗体。E抗原阳性，俗称“大三阳”。E抗原阴性，E抗体阳性，俗称“小三阳”。

"Big 3 this world"and"Small 3 this world"In patients with chronic hepatitis b infection is on the state of the two kinds of commonly known as.The conventional hepatitis b test has five second liver markers detection,namely"Second liver two half-and-half",They in turn is antigen of second liver surface,Antibody of second liver surface/Hepatitis b e antigen/Antibody of second liver E/Antibody of second liver core.E antigen positive,Commonly known as"Big 3 this world".E antigen negative,E antibody positive,Commonly known as"Small 3 this world".

　　实现“大三阳”转变为“小三阳”，其专业术语是E抗原血清学转换。中国医科大学附属盛京医院窦晓光教授认为，通过规范的抗病毒治疗，部分患者可以实现E抗原血清学转换，这是慢性乙肝患者治疗过程中的一个重要临床节点。

realize"Big 3 this world"into"Small 3 this world",The professional term is E antigen serology conversion.China medical university affiliated hospital professor think DouXiaoGuang shengjing,Through the standard arv treatment,Some people can realize E antigen serology conversion,This is chronic hepatitis b patients in the course of treatment an important clinical node.

　　高嘉宏表示同意窦晓光的观点，他进一步的阐释说，短期来看，E抗原血清学转换是抗病毒治疗的停药指征之一，意味着乙肝病毒复制在很长时期受到抑制，病情处于静止状态。长期来说，E抗原血清转换表示疾病进展停止或减缓，有望实现持续低水平的病毒复制、纤维化进程的停止或逆转、降低肝癌肝硬化的发生。(完)

GaoJiaHong agreed DouXiaoGuang point of view,He further explanation said,Short term,E antigen serology conversion is antiviral treatment discontinuation of indications,Means that hepatitis b virus replication in a very long period is restrained,The illness in a stationary state.Long term,E antigen serum conversion stop or slow disease progression said,Is expected to achieve sustained low levels of viral replication/Fibrosis process stop or reverse/To reduce the occurrence of liver cirrhosis.(finish)