乙型肝炎病毒（HBV）及其卫星病毒丁型肝炎病毒（HDV）必须通过结合细胞表面受体分子，才能实现对宿主细胞的感染。因此，如能找到该受体，将有助于深入理解乙肝感染机制，并为感染及相关疾病提供有用的治疗靶点。可是，这个难题在世界范围内几十年未能解决。北京生命科学研究所（下称北生所）的科学家经过数年攻关，终于发现了这一受体分子。

    Hepatitis b virus(HBV)And its satellite butyl virus hepatitis e virus(HDV)Must by combining cell surface receptor molecules,To realize the host cell infection.therefore,If you can find the receptor,Will help to understand mechanism of hepatitis b virus (HBV) infection,And for infection and related disease provide a useful therapeutic targets.but,The problem in the worldwide decades has not been able to solve.The life science research institute of Beijing(Next said north students)Scientists after several years research,Finally found this receptor molecules.

　　这项工作是由北生所研究员李文辉博士领导的科研团队完成的，研究成果在线发表在11月13日的《eLife》杂志上，题为“钠离子牛磺胆酸共转运多肽是乙型肝炎和丁型肝炎病毒功能性受体”。该杂志是国际生命科学领域的顶尖杂志。

This work is born from north of the dr. LiWenHui the leadership of the scientific research team to complete,Research results published online in a November 13[eLife]magazine,titled"Sodium ion taurocholic acid common transport peptide is hepatitis b and d type hepatitis virus functional receptors".The magazine is the international life science field top magazine.

　　据介绍，目前全球有超过3.5亿慢性乙型病毒性肝炎患者，其中1500万人同时还感染了乙肝卫星病毒HDV。我国约有1．2亿人携带乙肝病毒，其中慢性乙肝病人3000万，每年约35万人死于慢性乙肝相关疾病。虽然目前已有乙肝疫苗，但全球每年仍有近百万人死于乙肝和相关疾病，并伴随有相似数量的新报告病例。

According to introducing,At present the whole world has more than 350 million chronic viral hepatitis b patients,15 million of them have also infected with the hepatitis b virus HDV satellite.China has about 120 million person carries second liver virus,The chronic hepatitis b 30 million,Each year about 350000 people died in the chronic hepatitis b related diseases.Although at present had the hepatitis b vaccine,But the world every year there are still nearly ten thousand people died from hepatitis b and related diseases,And with a similar number of new report cases.

　　早在40多年前，人类就发现了乙肝病毒，但其相关的细胞表面受体却一直是未解之谜。全球多个知名科研机构的顶尖科学家在寻找乙肝病毒细胞表面受体。研究表明，迄今所发现的这些分子都不是乙肝病毒感染过程中起决定性作用的功能受体分子。

As early as in more than 40 years ago,Man found hepatitis b virus,But its related cell surface receptors are still unsolved mystery.Global many well-known research institutions top scientists are looking for hepatitis b virus cell surface receptors.Research shows that,So far have found these molecules are not hepatitis b virus infection play a decisive role in the process of the function of the molecular receptors.

　　李文辉团队自2007年起开始了相关研究。与灵长动物非常类似的小动物树鼩，是除人类和黑猩猩以外唯一能被乙肝病毒感染的物种。李文辉团队从树鼩入手，首先绘制了一幅高质量的树鼩肝细胞基因表达图谱。他们通过独创的纯化手段深入分析后发现，肝脏胆汁酸转运体（NTCP，牛磺胆酸钠共转运多肽）会与乙肝病毒包膜蛋白的关键受体结合域发生特异性相互作用。随后，他们在相关细胞中进行了一系列的实验，证明肝脏胆汁酸转运蛋白的确是病毒感染所需的细胞受体。

LiWenHui team since 2007 began the related research.And spirit long animals very similar small animals tree shrew,In addition to humans and chimpanzees are outside the only can be second liver virus infection of the species.LiWenHui team of from tree shrews,First draw a portrait of high quality tree shrew liver cell gene expression pattern.They through the original purification means the discovery after thorough analysis,Liver bile acid transport body(NTCP,Taurocholic acid sodium common transport polypeptide)With the hepatitis b virus envelope protein key receptor binding domain specific interaction happened.then,They in the relevant cells carried out a series of experiments,Prove liver bile acid transporters is indeed the virus infection cell receptors.

　　他们还鉴定出NTCP上关键的病毒结合区域。比如猴子的NTCP通常不能结合乙肝病毒，但只要突变其NTCP上一段极小的区域，就能使之变成有效的HBV和HDV受体。

They also identified the key NTCP virus in combination with regional.Such as the monkeys NTCP usually cannot be combined with hepatitis b virus,But as long as mutation its NTCP on a tiny area,Can make become effective HBV and HDV receptor.

　　李文辉团队的发现在国际同行中引发轰动。HBV病毒侵入研究领域的顶尖专家，德国海德堡大学教授史迪丰·吾本博士认为：“这一突出成果对HBV研究领域的影响不可低估”，“将改变HBV领域内现行的研究模式，将可能帮助乙肝治疗新药的发现而为乙肝病人造福。”（记者吴月辉、赵永新）

LiWenHui team found in international counterparts in caused a sensation.HBV virus intrusion in the research field of the top experts,Germany Heidelberg university professor ShiDiFeng · I this doctor thinks:"The outstanding achievements of HBV in the research field of the influence cannot underestimate","Will change HBV within the territory of the existing research mode,Hepatitis b may help to the discovery of new drugs for hepatitis b patients benefit."(Reporter WuYueHui/ZhaoYongXin)