中新网兰州12月3日电 (记者 冯志军)记者3日从甘肃省科技厅获悉，由兰州军区兰州总医院承担完成的省科技支撑计划“阻断高危型HPV浸染防治宫颈癌的技术研究”项目已取得阶段性成果。该项目充分利用当地中药资源，提供安全有效的抗人乳头状瘤病毒药物，以提高宫颈癌的防治水平，降低治疗成本。

Beijing on December 3, lanzhou (Reporter FengZhiJun)Reporters learned from gansu province 3, technology,Lanzhou military region by lanzhou general hospital for complete province science and technology support plan"Blocking high risk HPV disseminated type of cervical cancer prevention and control technology research"The project has made achievements.The project to make full use of the local resources of traditional Chinese medicine (TCM),Provide safe and effective resistance to human papilloma virus drugs,In order to improve the level of prevention and control of cervical cancer,Reduce the treatment cost.

　　宫颈癌的发病率在女性肿瘤中位居第二，是世界常见的重大疾病之一。这一项目采用医学、药学、化学信息学等多学科先进的技术对秃疮花、苦豆子、苦参中的抗人乳头状瘤病毒(HPV)的活性成分或部位进行筛选，对其活性成分或部位进行细胞实验体外及动物实验体内研究，明确具有抗人乳头状瘤病毒的成分或部位并进行分离提取，为将来制备药物制剂进行临床药效学、安全性研究。

The incidence of cervical cancer in women in the tumor in the second,Is the world common one of the major diseases.The project using medicine/pharmacy/Chemical informatics multidisciplinary advanced technology to spend favus of the scalp/Sophora alopecuroides/Bitter and resistance of the human papilloma virus(HPV)Active ingredients or parts of screening,The active components or parts of the cells in vitro and in vivo study animal experiments,Clear has good human papilloma virus components or parts and extraction,Preparation for future drug preparation for clinical pharmacodynamics/Safety research.

　　据了解，该项目实施三年来，通过对甘肃地道的中药材苦参及秃疮花等中药材的化学成份应用分子对接虚拟筛选等方法，找出可能具有抗人乳头状瘤病毒活性的化合物，如苦参碱、异紫堇碱等，并建立了相应的化合物结构数据库。

It is understood,This project for three years,Through the gansu authentic Chinese herbal medicine bitter and and favus of the scalp flowers such as Chinese herbal medicine the chemical composition of the application of molecular docking methods of virtual screening,Find out may have resistance to human papilloma virus active compounds,Such as matrine/Different purple violet alkali etc,And to establish the corresponding compound structure database.

　　同时，建立了体外抗人乳头状瘤病毒感染的宫颈癌细胞模型及非感染宫颈癌细胞模型，总结出较为系统的通过抑制人乳头状瘤病毒来预防和治疗宫颈癌的方法。该方法将有利于充分利用地方中药资源，制备具有西北特色的中药制剂，以提高宫颈癌及宫颈人乳头状瘤病毒感染的防治水平。(完)

At the same time,Established in vitro anti human papilloma virus infection of cervical cancer cell model and the infection cervical cancer cell model,Summed up the systematic by inhibiting human papilloma virus to the prevention and treatment of cervical cancer method.This method will help make full use of local resources of traditional Chinese medicine (TCM),Preparation of northwest characteristics of traditional Chinese medicine preparation,In order to improve the cervical cancer and cervical HPV infection prevention level.(finish)