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复旦学者发现男同“多性伴”易致艾滋病病毒变种--亲稳舆论引导监测室
2013-02-26

  复旦大学公共卫生学院何纳教授领衔的艾滋病研究课题组首次综合运用流行病学、分子生物学及行为网络理论等多学科方法,并深入现场,历经3年多艰辛,对100名已感染艾滋病病毒的男男性行为者和与之发生性接触的1534名男男性行为者进行溯源追踪调查,最终发现男男性行为人群艾滋病病毒的行为和分子传播新机制。

School of public health at fudan university AIDS research team, led by professor He Na integrated use of epidemiology for the first time/Molecular biology and behavioral multi-disciplinary methods such as network theory,And the scene,After more than three years,Of 100 have been infected with HIV/AIDS in men who have sex with men and with the occurrence of sexual contact of traceability tracking survey was conducted among 1534 men who have sex with men,Eventually found that male crowd behavior and HIV transmission mechanisms.

  新机制揭示,同一对男男性行为者,由于“多性伴”会导致感染不同基因亚型的艾滋病病毒,并由于艾滋病病毒具有快速复制和基因重组的能力而存在“诞生”新的艾滋病病毒品种的风险。该成果对我国男男性行为人群艾滋病的有效防控提供了重要的科学依据,并已发表在国际流行病学界的顶级期刊《美国流行病学杂志》上,引起国内外研究者关注。

New mechanism to reveal,The same to men who have sex with men,Due to the"Sexual partners"Can lead to different genetic subtypes of HIV infection,And because the AIDS virus has the ability of rapid replication and gene recombination"Was born"The risk of new varieties of the AIDS virus.The achievements of Chinese men act crowd AIDS provided important scientific basis for effective prevention and control,And has been published in the international epidemic of top journals[The American journal of epidemiology]On the,The researchers at home and abroad attention.

  男男性行为人群是指男男同性之间发生性行为的群体,其中除少数双性恋者和异性恋者外,绝大多数为通常所称的男同性恋者。1981年发现的世界第一例艾滋病病例就是男同性恋者,这一群体一直被全球公认为是艾滋病病毒感染的高危人群。2012年,我国针对男男性行为人群的艾滋病哨点监测发现,这一人群艾滋病病毒感染率达6.7%,在个别大城市,男男性接触传播占新报告发现的艾滋病病例甚至高达50%以上。

Behavior refers to the MSM crowd male same-sex sexual activity between groups,Along with a few bisexual and heterosexuals,The vast majority is usually described as a gay men.Discovery in 1981 of the world's first case of AIDS cases is gay,This group has long been acknowledged as the global AIDS virus infection of high-risk groups.In 2012,,In our country for men crowd found HIV sentinel surveillance,The crowd HIV infection rate was 6.7%,In some big cities,Contact with spread of the new report found that male AIDS cases as high as 50% above.

  何纳课题组通过艰辛工作,成功地绘制出以艾滋病病毒感染者为核心的“男男性行为人群性行为网络图”和“艾滋病传播链图”,结合基因亚型分析,清晰地阐明了男男性行为人群中艾滋病传播的行为和分子机制。何纳认为,为防控艾滋病进一步蔓延,国家相关部门在加大力度宣传“男男性行为者应进一步减少性伙伴和推广使用安全套”的基础上,采取更加切实可行的干预措施,如进一步扩大男男性行为人群的艾滋病病毒检测,尽早发现传染源,尽早启动抗艾滋病病毒治疗措施,以降低感染者体内艾滋病病毒数,从而达到降低传染性的目的。(首席记者 施捷 通讯员 孙国根)

He Na group through hard work,Successfully mapped with HIV as the core"Male sex behavior people network diagram"and"HIV/AIDS transmission chain diagram",Gene subtype analysis,Clearly illustrates the behavior of male behavior and the molecular mechanism of the spread of AIDS in the crowd.He Na think,For the prevention and control further spread of HIV/AIDS,National related departments to intensify efforts to propaganda"Men who have sex with men should further reduce the partners and promoting condom use"On the basis of,Take a more practical interventions,As further actions male population of HIV testing,Found the source of infection as soon as possible,Start the anti-hiv treatment as soon as possible,In order to reduce the number of people infected with the AIDS virus HIV,So as to achieve the aim of reducing infectious.(Chief reporter ShiJie correspondent Sun Guogen)


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