受访专家/广东省中医院生殖医学科副主任医师 陆杉 Interviewed experts/guangdong hospital of reproductive medicine of doctor of vice director of LiuSha

　　通常，女性会在45-55岁进入围绝经期，逐渐出现月经的改变，然而最近发现,门诊中出现了不少40岁左右的年轻女性,反映提前进入围绝经期。专家表示，尤其是受到高等教育的女强人，她们工作压力大，心情上较为紧张，时间一长，身体内分泌就容易出问题。

usually，Women in 45 to 55 years old into the menopausal transition，Gradually appear menstrual changes，However the most recently discovered,Outpatient service appeared many 40 of young women,Reflect the advance into the menopausal transition。Experts say，Especially in higher education of a strong woman，They work pressure，The mood is tense，Time a long，The body endocrine easy problems。

三四十岁出现月经稀发或闭经 40 years old appear menstrual thin hair or amenorrhea

　　广东省中医院生殖医学科副主任医师陆杉说，在临床上，不少三四十岁的女性因为闭经来医院就诊，经过检查才发现，卵巢里已经没有卵泡或者只有少数卵泡，抽血内分泌检查发现，其促性腺激素高、促黄体素高，而雌激素低，已经达到了更年期的水平。从这几点看八九不离十是卵巢早衰了。

Guangdong hospital of traditional Chinese medicine reproductive medicine of doctor of vice director of LiuSha said，In the clinical，A lot of 40 years old female because amenorrhoea to hospital，After inspection found that，Ovarian have no follicle or only a few follicle，Exsanguinate endocrine findings，Its gonadotropin high、Promoting corpus luteum high，While estrogen low，Has reached the level of the menopause。From this time look pretty close is the premature ovary。

　　在门诊里，还有人是因为想祛除脸上的色素斑，或者是因为阴道干涩、性冷淡来就诊，甚至还有一些人是不孕不育来就诊，结果检查才发现是卵巢早衰，每当一听到这样一个结果，这些年轻女性往往很难接受这一事实。陆杉强调，过度减肥也会卵巢早衰，因为脂肪组织是体内除卵巢以外制造雌激素的重要场所。因此，过度减肥会造成内分泌紊乱，出现月经紊乱，甚至卵巢早衰。

In the outpatient service，Others because they want to get rid of the face of the pigment spots，Or because the vaginal dry、Sex apathy to see a doctor，There are even some people are sterility to see a doctor，Results inspection found that is premature ovary，Whenever a hear such an outcome，These young women often hard to accept the fact。LiuSha emphasize，Excessive weight loss will also be premature ovary，Because adipose tissue is the body other than in addition to ovarian estrogen manufacture important place。therefore，Excessive weight loss can cause endocrine disorder，Appear menstrual disorder，Even premature ovarian。

　　实际上，卵巢早衰并不是一开始就闭经，而是先从月经不规律到停经，这期间有个变化过程，时间的长短因人而异，半年到一年之间。所以说，卵巢早衰是有先兆的，在发病前多出现月经紊乱(频发)———月经稀发———闭经的变化过程，因此，女性要重视月经改变。有些女性粗心大意，或者毫不重视，甚至认为来不来无所谓，直到出现严重症状，才着急来就诊。

In fact，Premature ovarian and is not a beginning amenorrhea，But the first menstruation to be not rule to menopause，This time a change process，The length of time is different from person to person，Between six months to a year。so，Premature ovarian is a premonitory，Before it appears more menstrual disorder(frequent)--, menstrual thin hair - amenorrhoea change process，therefore，Women should attach importance to menstrual changes。Some of the women's carelessness，Or not pay attention to，Even think coming or not doesn't matter，Until severe symptoms，Just try so hard to see a doctor。

精神压力大会致更年期提前 Mental pressure congress to menopause in advance

　　卵巢早衰在现代社会来说，并不少见。据调查，卵巢早衰在成年女性中占1%-3%，从40岁开始，有一部分女性闭经，这可以认为是步入了绝经期，但如果40岁之前就出现闭经，那很有可能就是卵巢早衰。

For premature ovarian in modern society，Is not rare。According to the survey，Premature ovarian in adult women 1% - 3%，From the age of 40，There is a group of women amenorrhea，This can be considered into the menopause，But if 40 years old before it appears amenorrhoea，It probably is premature ovary。

　　通常，女性会在45-55岁才进入围绝经期，而在门诊中为什么这么多年轻女性也会提前进入围绝经期呢？陆杉说，卵巢早衰的原因较为复杂，从下丘脑———垂体———卵巢，任何一个环节出问题，都可能导致卵巢“提早退休”。

usually，Women in 45 to 55 years old before he enter the menopausal transition，And in outpatient service why so many young women will advance into the menopausal transition？LiuSha said，The cause of premature ovary is relatively complex，From the hypothalamus pituitary ovary -- --，A part of any problems，Could lead to ovary“Early retirement”。

　　陆杉指出，在门诊中，出现卵巢早衰的女性可以出现在各个年龄段，从18岁的学生到30岁的农妇都有。也有一部分是受到高等教育的女强人，她们多数从事金融、策划、营销、公关、广告之类职业，她们其实内心压力大，心情上较为紧张，时间一长，身体内分泌就容易出问题。

LiuSha pointed out that，In the outpatient service，Appear premature ovary of female can appear in all age groups，From 18 years old students to 30 years old woman has。Also has a part is in higher education of a strong woman，They most engaged in financial、planning、marketing、Public relations、Such as advertising professional，They actually inner pressure，The mood is tense，Time a long，The body endocrine easy problems。

　　另外，一过性精神刺激也会造成女性卵巢早衰。曾经就接诊到一名女患者，因为父亲突然去世，给她巨大的精神打击，持续一年时间都郁郁寡欢。后来她就出现了色斑、脱发、失眠等问题，月经也稀稀拉拉，一检查就出现了卵巢早衰的迹象。其实，卵巢是一个很感性的器官，在人处于悲伤、压抑等精神状态时，它就处于应激状态，时间久了，卵巢组织细胞受损。

In addition，A had sexual mental stimulation can also cause premature ovarian women。Once it accepts to a female patients，Because my father died suddenly，To her great shock，For a year are in low spirits。Later she appeared splashes、Hair loss、Problems such as insomnia，Menstruation also slowed，A check is appeared signs of premature ovary。In fact，Ovary is a very perceptual organs，In people in sadness、Depressive mental state，It is in the stress state，Time is long，Ovarian tissue cell damage。

卵巢早衰没有好的治疗办法 Premature ovarian without a good treatment

　　患上卵巢早衰，长期处于低雌激素状态下，女性会发生子宫萎缩，阴道分泌物减少，性交痛，甚至长期缺钙以致骨质疏松等症状，这才来医院就诊。遗憾的是，如果确诊为卵巢早衰，目前并没有很好的办法治疗，因为卵巢功能的恢复是极其困难。

From premature ovarian，In the long run, low estrogen state，Women will occur uterine atrophy，Vaginal secretions reduce，Sexual pain，Even the long-term lack calcium so that the symptom such as osteoporosis，This just to hospital。It is a pity that，If diagnosed as ovarian premature senility，At present there is no good way to treatment，Because ovarian function recovery is extremely difficult。

　　陆杉说，对于40岁才想生孩子的高龄女性，由于卵巢功能衰退，要怀孕的概率并不高。“但还是有一部分患者能抓住卵巢功能过渡期的机会得以怀孕，这样的好运不超过5%的几率。”今年40岁的陆女士，在5年前就发现促卵泡素及促黄体素升高(相当于更年期水平)，当时吃了一个疗程的人工周期后复查指标恢复正常，后来陆续服用雌激素，在3年前顺利生下1个男孩。最近6个月都没来月经，查性激素提示促卵泡素高达60IU/L左右，雌激素及孕激素明显低下。由于已完成了生育目的，就可以采用激素替代，维持正常月经周期即可。

LiuSha said，For 40 years old to want to have children at the age of the female，Because of ovarian function decline，Should pregnant probability is not high。“But there are still part of the patients can seize the ovarian function transition opportunities to conceive，Such good luck not more than 5% chance。”This year at the age of 40 ms lu，In the five years ago found follicle-stimulating hormone and luteinizing element rise(Equivalent to the level of menopause)，At that time had a course of artificial cycle review index returned to normal，In succession later to estrogen，In the three years ago smooth gave birth to a boy。For the last 6 months has come to menstruation，Check sex hormones prompt follicle-stimulating hormone as high as 60 iu/L or so，Estrogen and progestogen low obviously。Due to have finished the purpose of childbearing，Can use the hormone replacement，Maintain normal menstrual cycle can。

　　“对于一部分有少许卵泡的女性，通过治疗也可以生育，比如西医多采用雌、孕激素的人工周期疗法，达到来月经或者促排卵的目的。不过，这种疗效只在服用药物期间或者服药后短期内有效。”陆杉说，“对另一部分卵巢里没有卵泡的女性，就再也没办法生育了。”(记者 张华 通讯员 吴远团 宋莉萍)

“For the part with a little follicle of women，Through the treatment can also fertility，Such as western medicine used more female、Progestational hormone artificial cycle therapy，To achieve the purpose of promoting ovulation period or。but，The effect of the drug only in during or after taking the effective in the short term。”LiuSha said，“To another part ovarian there is no follicle of women，There was no way to breed。”(Reporter correspondent zhang hua WuYuan SongLiPing group)