中新社上海12月5日电 (记者 邹瑞玥)最新一期的世界顶级学术期刊《美国国家科学院(PNAS)》发布了上海交大研究团队一项重要成果。上海交大系统生物医学研究院教授吴强的科研团队发现一种特殊蛋白质调控机理，阐明了原钙粘蛋白家族在大脑中细胞特异性表达的分子机制。这一研究成果对科学家破解人类基因组的编码调控机制，以及破解精神疾病发病机理将产生深远影响。

China news agency on December 5, Shanghai (Reporter ZouRuiYue)The latest issue of the world's top academic journal[The United States national academy of sciences(PNAS)]Shanghai jiaotong university research team released an important achievements.Shanghai jiaotong university system biomedical research institute professor WuJiang research team found that a kind of special protein regulation mechanism,To clarify the original cadherin family in the brain cells express specific molecular mechanism.The research results to scientists decode the human genome encoding regulation mechanism,And crack mental disease pathogenesis will produce profound influence.

　　上海交大系统生物医学研究院教授吴强5日介绍，人脑含有上千亿个不同的神经细胞，每个神经细胞又形成上万个特异性突触连接。如同世界上没有两片完全相同的树叶一样，人脑的神经细胞也各不相同，而构成其差异的“身份密码”就是由“原钙粘蛋白群”决定的。吴强说，如精神分裂症、自闭症、抑郁症，甚至脑肿瘤等大脑疾病，都可能是因为神经细胞某种蛋白质表达出现问题。如今这一“身份密码”如何产生得以破解，对于研究此类疾病机理将起到关键作用。

Shanghai jiaotong university system biomedical research institute professor introduced WuJiang 5th,The human brain contains billions of different nerve cells,Every nerve cell and formation of thousands of specific synaptic connections.As there are no two leaves are exactly the same as,The human brain nerve cells also each are not identical,And constitute its differences"id"Is the"The original cadherin group"decision.WuJiang said,Such as schizophrenia/autism/depression,Even a disease of the brain, brain tumors, etc,May be because of nerve cells some protein expression problems.Now the"id"How to produce to crack,To research this kind of disease mechanism will play a key role.

　　吴强形容说，人的每个基因都有若干个激发其活性的“发动机”，称为“启动子”；还有一个增强其活性的“加速器”，称为“增强子”。在一条DNA染色体上，它们往往相隔甚远，它们如何自选组合决定了细胞的差异性，而它们如何选择、连结，是由“绝缘子结合蛋白CTCF”和“染色体粘连蛋白Cohesin”决定的。二者都至关重要，不可或缺，它们控制着原钙原蛋白“启动子”的选择，组成每个神经细胞独特的“身份密码”。

WuJiang describe said,Person's each gene has several arouse their activity"engine",called"promoter";And an enhanced its activity"accelerator",called"enhancer".On a chromosome DNA,Often they are very far apart,How they optional combination determines the cell difference,And they how to choose/links,Is by"Insulator binding protein CTCF"and"Chromosome adhesion Cohesin protein"decision.Both are very important,indispensable,They control the original calcium original protein"promoter"choice,Every nerve cell of unique"id".

　　国际评审专家对于该研究给予高度评价，认为其揭示的调控机制在基因表达调控领域具有广泛意义。专家认为，进一步的研究将有助于人们对复杂神经网络形成机理的理解，并促进对脑肿瘤、精神分裂症、自闭症等大脑疾病发病机制研究。(完)

International evaluation expert for the study to give the high evaluation,Think its reveals control mechanism in regulating gene expression meaning is widely.Experts say,Further research will help people to the complex neural network to understand the formation mechanism of,And promote the brain tumor/schizophrenia/Autism is a disease of the brain, such as the mechanism.(finish)