中新网昆明12月25日电 (顾一航 张刚强)近年来，科学研究证实人的大脑容量具有很高的遗传力。记者25日从中科院昆明动物研究所获悉，该所科学家通过研究发现影响脑容量变化的基因，进一步揭示了人类脑容量的遗传基础。

Beijing on December 25, kunming (The a air tickets are strong)In recent years,Scientific research confirmed that the human brain capacity has the very high genetic force.Reporter 25 from the Chinese academy of sciences institute of kunming animals learn,This study found that the scientists affect brain capacity change gene,Further reveals the genetic basis of human brain capacity.

　　神经系统是人类区别于其他物种最显著的特征之一。相对于其他物种，人类的大脑高度发达，主要体现在全脑容量的变化。如人类的大脑容量是旧大陆猴-如猕猴脑容量的20.6倍，长臂猿的14.4倍，与人类亲缘关系最近的灵长类-黑猩猩的4.3倍。

The human nervous system is different from other species, one of the most striking features.Relative to other species,The human brain is highly developed,Mainly embodied in the whole brain capacity changes.Such as the human brain capacity is old world monkeys - such as rhesus monkey brain capacity of 20.6 times,Gibbon 14.4 times,And human genetic relationship recent primates - 4.3 times that of chimpanzees.

　　近年来，基于核磁共振脑影像学研究表明脑容量具有很高的遗传力，并且与智商和记忆等认知能力高度相关。除此之外，脑容量在多种精神疾病(如精神分裂症)患者中均发生了明显病变。然而，截止到目前为止，仅仅只有少数几个基因被发现与脑容量相关。

In recent years,Based on the nuclear magnetic resonance (NMR) brain imaging studies show that brain capacity has the very high genetic force,And with intelligence and memory and cognitive ability high correlation.In addition,Brain capacity in a variety of mental illness(Such as schizophrenia)Patients are changed obviously lesions.however,Up to now,Only a handful of genes was found and brain capacity related.

　　为了寻找可能影响脑容量变化的基因，中科院昆明动物研究所宿兵实验室选取了50个精神分裂症易感基因，并在中国汉族人群中分析了它们与脑容量的关系，最终发现白介素-3基因序列变异与脑容量强烈相关。随后，通过国际合作，他们在欧洲人群中也重复了这一结果。

In order to find may affect the brain capacity change gene,Kunming institute of the Chinese academy of sciences laboratory animals were selected SuBing fifty susceptibility genes of schizophrenia,In China and the han people and their analysis of the relationship between the brain capacity,Finally found interleukin (il) 3 gene sequence variation and brain capacity strong correlation.then,Through the international cooperation,They crowd in Europe also repeat the results.

　　研究结果显示，白介素-3除了在免疫系统中的已知功能之外，还参与中枢神经系统的发育，促进神经前体细胞的增殖和存活能力，从而影响脑容量。除此之外，通过体外实验，研究人员还发现了白介素-3基因性别特异性相关的可能机制，即它可以活化雌激素受体，并诱导下游的信号通路。

The results showed that,Interleukin (il) 3 in the immune system in addition to the known outside the function,Also participate in the development of the central nervous system,Promote neural precursor cells proliferation and survival ability,Which affects brain capacity.In addition,Through the in vitro experiment,The researchers also found gender specific interleukin (il) 3 genes related to the possible mechanism,That it can activate estrogen receptor,And induced the downstream signaling pathways.

　　负责该项目的科研人员介绍：“该研究进一步揭示了人类大脑容量的遗传基础，对于我们理解精神疾病的发病机制以及神经发生的分子机制都具有重要的意义。”(完)

Responsible for the purpose of scientific research personnel is introduced:"The study further revealed the genetic basis of human brain capacity,For us to understand the pathogenesis of mental illness and neurogenesis molecular mechanism is of great significance."(finish)