中新网上海12月28日电 (郭跃武张旦昕陈静)肿瘤表面拥有一层厚厚的“糖衣盔甲”，因此常规化疗时，药物很难突破这一屏障而达到令人满意的疗效。如何破解这个难题？

Beijing Shanghai, 28 dec (GuoYueWu ZhangDanXin borkhard)The surface has a thick layer of tumor"Sugar coating armor",Therefore the conventional chemotherapy,Drugs it is difficult to break through the barriers and achieve satisfactory curative effect.How to solve the problem?

　　上海交通大学附属第六人民医院检验科主任高锋教授课题组潜心攻关，利用生化手段，在基础研究中将“糖外衣”分解片段，并最终击碎肿瘤“糖衣盔甲”。

6 people's hospital affiliated to Shanghai jiaotong university, director of the laboratory director professor group with concentration research,Using chemical means,In the basic research will be"Sugar coat"Decomposition fragments,And eventually break tumor"Sugar coating armor".

　　据披露，此项“以毒攻毒”的研究成果发表在新近出版的国际生物化学界顶级刊物《生物化学杂志》(JBiolChem2012年12月刊)上。专家认为，该项研究为肿瘤化疗提供了有力的理论证据，同时也开辟了肿瘤靶向治疗的新路径。

According to the disclosure of,the"The dog that bit you"Research published in the latest issue of the international biological chemical industry top journals[Journal of biological chemistry](December JBiolChem2012 issue)On the.Experts say,The study of tumor chemotherapy provides a strong theoretical evidence,At the same time also opened up a new path of targeted therapy of cancer.

　　据高锋介绍，人体细胞表面有无数的分子环绕着，医学上统称为细胞外基质成分。肿瘤发生时，这些分子会发生成分改变，其中有部分肿瘤如乳腺癌、结肠癌、头颈部癌等的细胞表面会出现膜受体重新分布、膜受体被诱导而局部聚集成簇的现象。由此肿瘤表面形成了一层厚厚的“糖衣盔甲”，这也是导致疗效不佳的症结之一。

Introduce according to the director,There are countless molecules around the cell surface human body,Collectively referred to as the extracellular matrix components on medicine.Tumor occurs,These molecular composition change happens,There are some tumors such as breast cancer/Colon cancer/Head and neck cancer and so on the cell surface membrane receptor will appear again/Membrane receptor was induced and local gathered together into a cluster phenomenon.The tumor formed a thick layer of the surface"Sugar coating armor",This is one of the key leading to poor curative effect.

　　据了解，透明质酸是细胞外最多的糖分子，它与细胞的连接首先要通过受体CD44相互作用，在细胞外形成富含水的微环境。高峰说，这个微环境就好比细胞穿上了衬衣，而当乳腺癌形成时，这件衬衣变成了厚厚的羽绒服并把肿瘤保护起来。

It is understood,Hyaluronic acid is extracellular most of sugar molecules,It connected to the cell must first through receptor CD44 interactions,Outside the cell formation in the microenvironment of water.Peak said,The micro environment is like cells on the shirt,When breast cancer formation,This shirt became thick down and protected the tumor.

　　多年来，国内外的科学家们一直试图找到破解保护衣的手段，以期在化疗时，能够让药物有效地进入肿瘤细胞里面。高锋课题组曾试图用HA消化酶、抗体等方法，但这些手段用到活体时，都会被体内相应的酶消化分解掉，因此难以完全奏效。

For many years,At home and abroad, the scientists have been trying to find means of crack protective clothing,So when the chemotherapy,Can drug into tumor cells effectively.Director of research tried to use HA digestive enzymes/Antibodies and other methods,But these methods used in vivo,Will be in the body of the corresponding digestive enzyme decomposition,So hard to work.

　　“能不能利用不会被分解的分子取代HA消化酶和抗体呢？”在这个思路的引导下，课题组于2008年瞄准了HA本身的分解片段，即透明质酸寡分子(oHA)，因为oHA在活体内不会再被继续消化分解。oHA与HA在肿瘤细胞周围对准的是同一个分子，即CD44。而小片段透明质酸分子与天然透明质酸的生物学功能却截然相反，它们与CD44结合后不会形成“糖衣盔甲”，由此肿瘤表面的保护性外衣就有可能被攻破。

"Can use won't be replaced by the decomposition of the molecular HA digestive enzymes and antibody?"Under the guidance of this idea,Group in 2008 at the decomposition of the HA itself,The hyaluronic acid that molecules(oHA),Because oHA in vivo won't continue to be breakdown.OHA with HA around the tumor cells at the same molecules,That CD44.And small fragments hyaluronic acid molecules and biological function of natural hyaluronic acid is quite the opposite,They combine with CD44 won't form"Sugar coating armor",The tumor on the surface of the protective coat can be taken by storm.

　　论文第一作者杨翠霞博士及课题组进行了三个阶段的研究，应用纳米手段将药物连接到oHA上，并伪装形成肿瘤细胞的“盟友”，潜入肿瘤表面，有效攻击“糖衣盔甲”，这一方法已在动物体内得到了验证：对照组的结果表明，该方法使化疗药物治疗肿瘤模型的疗效提高了百分之五十。

Lead author Dr. YangCuiXia papers and research on the three stages of our group,On the application of nano means connect drugs to oHA,And camouflage formation of tumor cells"ally",Into the tumor surface,Effective against"Sugar coating armor",This method has been verified in the animal body:The results show that in the control group,The method makes the curative effect of chemotherapy drugs therapy model increased by fifty percent.