中新社合肥3月5日电 (杨保国 吴兰)记者5日从中国科技大学获悉，该校生命学院和微尺度物质科学国家实验室研究人员发现，自然杀伤细胞对维持胚胎免疫耐受具有重要调控作用，揭示胚胎免疫的AB面，相关成果发表在《自然-通讯》等国际权威期刊上。

March 5 (xinhua) China news service in hefei (Yang Baoguo Wu Lan)5, reporters learned from China university of science and technology,The college life and micro-scale material science national laboratory researchers found,Natural killer cells plays an important regulatory role in immune tolerance maintain embryos,Reveal the embryo immunization AB face,Relevant published in[Nature communications]And other international authoritative journals.

　　妊娠是一个复杂的生理过程，胚胎对于母体来说是一个基因不合的异物，母体免疫系统识别后会发生免疫排斥，类似于器官移植后的排斥反应。但在正常情况下，胚胎不会受到母体的排斥而发育存活，这就是胚胎免疫耐受。其机制此前尚不清楚。

Pregnancy is a complex physiological process,Embryo is a gene for maternal out foreign bodies,What will happen when maternal immune system identification of immune rejection,Similar to the rejection after organ transplantation.But in normal circumstances,Embryos from maternal rejection of survival and development,This is the embryonic immune tolerance.Its mechanism is unclear.

　　中国科大研究人员发现，在妊娠过程中，母-胎界面存在大量与众不同的自然杀伤细胞(NK细胞)，天然杀伤能力很低，但可以产生伽马干扰素，抑制由于胚胎基因不合而产生的炎症细胞Th17，并将Th17的作用控制在正常生理范围内，使母体对胎儿并不产生排斥反应，而是产生保护性免疫作用。

Chinese university researchers found,In the process of pregnancy,Mother - child interface there are many different natural killer cells(NK cells),Natural killer ability is low,But can produce gamma interferon,Inhibition of inflammation caused by embryonic genes and Th17 cells,And the role of Th17 control in the normal physiological range,The mother to the fetus is not producing rejection,But to produce protective immune effect.

　　研究人员之一博士后傅斌清解释说，如果母体同时遭遇病毒等病原体感染，会产生大量Th17细胞，导致炎症反应，自然杀伤细胞失去抑制能力，甚至暴露出杀伤的真面目，加剧胚胎局部的免疫反应和炎症反应，最终导致胚胎丢失或流产。尽显自然杀伤细胞与胚胎免疫的“恶人”与“卫士”AB面。相关研究成果日前发表在《美国科学院院刊》。

One of the researchers postdoctoral Fu Binqing explained,If the mother also encountered pathogens such as viral infections,Will produce a large number of Th17 cells,Lead to inflammation,Natural killer cells lose inhibition,Even exposed the killer's face,Adding embryonic local immune reaction and inflammation reaction,Eventually leading to abortion or embryo loss.All show natural killer immune cells and embryos"The wicked"With the"The guard"AB face.Recently published in the related research achievements[Proceedings of the national academy of sciences].

　　为什么胚胎局部的自然杀伤细胞失去杀伤功能，而变成维持母胎免疫耐受的卫士？研究者之一倪芳博士介绍，随后该课题组又利用微小RNA芯片技术进行筛查，首次发现胚胎局部的自然杀伤细胞富含一种微小核糖核酸分子miR-483-3p，该分子在胚胎自然杀伤细胞中的含量是正常自然杀伤细胞含量的近万倍，导致胚胎自然杀伤细胞不能分泌生长因子IGF-1，失去杀伤功能，转而分泌伽马干扰素，维持免疫调节功能。该研究从新的理论角度解释了胚胎免疫耐受的分子机制，相关成果发表在2月的《自然-通讯》上。

Why does embryonic local natural killer cells lose killing function,And maintain the defenders of maternal-fetal immune tolerance?One of the researchers Dr NiFang is introduced,Then the group also USES tiny RNA chip technology screening,First discovered the embryo of local natural killer cells contain a tiny RNA molecules miR - 483-3 p,The molecular levels of natural killer cells in embryo nearly ten thousand times the normal content of natural killer cells,Natural killer cells in embryonic can secrete growth factors igf-1,Lost killer function,To secrete gamma interferon,To maintain the immune regulating function.The study from the perspective of the new theory explaining the embryonic molecular mechanism of immune tolerance,Relevant published in February[Nature communications]On the.

　　《自然-通讯》审稿人则评价说，这项研究发现了IGF-1在人类自然杀伤细胞中的新功能，即IGF-1对自然杀伤细胞的杀伤功能具有促进作用，这将对NK细胞的临床生物治疗具有重要意义。(完)

[Nature communications]The reviewer comments,The study found the igf-1 in the new features of human natural killer cells,The igf-1 has a promoting effect on killing function of natural killer cells,This will be the clinical biological treatment of NK cells is of great significance.(After the)