中新社上海3月6日电 (记者 邹瑞玥)上海交大特别研究员、Bio-X研究院博士李卫东与美国学者合作的一项研究成果，发布在最新一期Cell子刊、神经科学顶级期刊Neuron杂志上。该研究发现，通过抑制mTOR信号途径，能改善大脑特殊区域基因缺失引发的认知和情感障碍，并指出针对这些细胞的治疗，对精神分裂症的治疗或将产生显著的疗效。

China news agency in Shanghai on March 6 (Reuters) (The reporter Zou Ruiyue)Shanghai jiaotong university researcher in particular/Bio - X research institute, Dr. Li Weidong of a study published in collaboration with the American scholar,Published in the latest issue of Cell ZiKan/Journal of neuroscience top journal Neuron.The study found that,By inhibiting mTOR signaling pathways,Special area can improve the brain gene loss caused by the cognitive and affective disorders,And points out that the treatment for these cells,For the treatment of schizophrenia or will have a significant effect.

　　精神分裂症被称为最严重的精神疾病，在世界各国人群中发病率为1%，其病因迄今尚未阐明。遗传因素是精神分裂症最主要的致病因素，人类基因学的研究发现一些极有研究前景的的精神分裂症易感基因。其中的Disrupted-in-Schizophrenia-1(DISC1)基因被认为是当今最有价值的精神分裂症及抑郁症等精神疾病的易感基因之一。此染色体易位携带者容易发展成为精神分裂症、抑郁症、躁郁症等精神疾病患者。DISC1基因引起了精神分裂症研究领域的极大关注，因为这是迄今发现的与精神疾病关联的第一个明确的变异基因。

Schizophrenia is known as the most serious mental disease,Crowd incidence was 1% in the countries all over the world,Its etiology has not yet been elucidated to date.Genetic factor is the most important pathogenic factors of schizophrenia,Human genetics research found that some research prospects of susceptibility genes of schizophrenia.The Disrupted - in - Schizophrenia - 1(DISC1)Gene is considered to be today's most valuable susceptibility genes of schizophrenia and depression and other mental illnesses.The chromosome translocation carriers to develop schizophrenia/depression/Patients with bipolar disorder and other mental diseases.DISC1 gene has attracted great attention in the field of schizophrenia research,Because it is associated with mental illness in the first ever found in specific genetic variants.

　　李卫东与美国加州大学洛杉矶分校、约翰霍普金斯大学等校学者合作，他们发现，通过抑制mTOR信号途径，能改善大脑特殊区域基因缺失引发的认知和情感障碍。如果利用一种FDA批准的抑制剂进行处理，可以纠正mTOR信号途径的不良反应，从而预防和治疗这种行为缺陷。

Li Weidong and the university of California, Los Angeles/Johns Hopkins university school scholars such as cooperation,They found that,By inhibiting mTOR signaling pathways,Special area can improve the brain gene loss caused by the cognitive and affective disorders.If using a fda-approved inhibitors for processing,Can correct mTOR signaling pathways of adverse reactions,Defect prevention and treatment of this kind of behavior.

　　研究认为，神经发育障碍疾病中出现的情感和认知缺陷表型，可能部分是由于成年期神经元发育过程异常而造成的，因此，针对这一细胞群的治疗，也许能对这些缺陷表型产生显著的疗效。(完)

Research suggests that,Neurodevelopmental disorders emotional and cognitive impairment in disease phenotypes,May be partly due to adulthood abnormal neuronal development process,so,For a cell group therapy,Phenotypic these defects may be able to have a significant curative effect.(After the)