7岁女孩埃米莉·怀特黑德如今有大把的时间去做她喜欢的事情：和混血宠物狗露西在花园里嬉戏；趴在床上一边读她喜欢的故事书，一边听流行音乐天后泰勒·斯威夫特的乡村民谣；甚至在家里练习空手翻和英国橄榄球式的打滚。

7 years old girl Emily whitehead now have a lot of time to do the things she likes:And the half-blood pet dog Lucy play in the garden;On the bed side to read her favorite story books,While listening to pop music days Taylor swift's country folk;Even in the home empty-handed and British football practice double roll type.

　　你恐怕难以想象，就在2012年春天，这个美国小姑娘差点死于白血病。她两次在化疗之后旧疾复发，而医生已经束手无策了。

I'm afraid you hard to imagine,In the spring of 2012,The American girl nearly died of leukemia.She is two times in the old disease recurrence after chemotherapy,But doctors have at the end of his tether.

　　但她最终战胜了病魔。最令人难以置信的是，前来助阵的是另一个臭名昭著的家伙——艾滋病病毒。来自美国宾夕法尼亚大学的科学家，使用一种丧失传染力的艾滋病病毒在基因层面重新编码了埃米莉的免疫系统，从而杀死她体内的癌细胞。换句话说，这种疗法赋予了患者自己的免疫系统与癌症持久战斗的能力。

But she finally beat the cancer.The most incredible is,To the companion is another notorious guy - the AIDS virus.From the United States scientists at the university of Pennsylvania,The use of a loss of infectious virus on the gene level recode the Emily's immune system,So as to kill her cancer cells in the body.In other words,This kind of therapy gives the patient's own immune system to fight cancer lasting ability.

　　这个笑起来带着深深酒窝的小女生，也因此在人类医学史上留下一笔，成为由艾滋病病毒改造自身T细胞疗法治愈的第一位白血病儿童。这项成果由宾夕法尼亚大学艾布拉姆森癌症研究所转化医学中心和费城儿童医院合作完成。该转化医学中心主任卡尔·琼颇为振奋地表示，埃米莉的治愈不仅说明了这种治疗方式的有效性，还预示它将治疗乳腺癌、前列腺癌等其他癌症。琼甚至希望，新疗法最终将取代骨髓移植，成为治疗白血病的常规疗法。

The smile with deep dimples little girl,So in the human medical history leaves a pen,Become the AIDS virus transform their T cell therapy to cure first leukemia children.The results from the university of Pennsylvania abramoff's institute for cancer research into medical center and the children's hospital of Philadelphia collaboration.The transformation of medical center director Karl Joan was inspired to express,Emily's heal not only illustrates the effectiveness of the treatment,Predicted it will cure the disease/Prostate cancer and other cancers.Joan even hope that,The new therapy will eventually replace a bone marrow transplant,Treatment for leukemia become routine therapy.

　　在生命垂危之际，埃米莉选择了“以毒攻毒”——利用艾滋病病毒治疗白血病

In the dying,Emily chose"Set a thief to catch a thief"- using HIV treatment for leukemia

　　2010年5月的一天，刚过完5岁生日的埃米莉突然流起了鼻血。当天晚上，父亲汤姆下班后，发现女儿鼻子上还留着深红色的凝固血渍。

In May 2010 a day,Just over the five years old birthday Emily suddenly flow played a nosebleed.That night,Father Tom after work,Found his daughter nose also has deep red solidification bloodstain.

　　按说，这不是什么大事儿，但汤姆告诉《中国青年报》，埃米莉很少流鼻血，而且流了好长时间才止住。为保险起见，他和妻子卡丽带着孩子到宾夕法尼亚州的赫尔希医学中心做了检查。医生得出的结果令人大吃一惊：他们唯一的孩子患上了急性淋巴细胞白血病。这种白血病是儿童癌症中最为常见的一种，大约有90%的治愈率。据统计，全球每年患白血病的人数达30余万。

ordinarily,This is not what big business,But Tom told[The China youth daily],Emily rarely flow nosebleed,And flow for a long time to stop.For insurance for the purpose of,He and his wife Carrie took the children to Pennsylvania hirsch checked medical center.The doctor of result very surprising:Their only children with acute lymphocytic leukemia.The leukemia is the most common childhood cancer a,About 90% of the cure rate.According to the statistics,Each year the number of people around the world suffer from leukaemia 30 more than.

　　然而埃米莉的病情很顽固，化疗对她几乎不起什么作用。随着病情的反复，医生不得不加大化疗药量，却发现小女孩被治愈的几率越来越低。

However Emily's condition is very stubborn,Chemotherapy for she almost didn't work.With the repeated illness,Doctors have to increase the dose of chemotherapy,But found the little girl be cured chance more and more low.

　　到2012年1月时，医生不得不押上最后一根稻草——骨髓移植。在治疗白血病及相关疾病的其他疗法失败时，骨髓移植是最后一丝希望。但就在离移植还有两周的时间，埃米莉的病情又复发了。由于病情缓解的时间过短，她无法接受骨髓移植手术。两个月后，医生宣布了埃米莉的生命垂危。

To in January 2012,Doctors have to joab last straw - a bone marrow transplant.In the treatment of leukemia and other related diseases therapy failed,Bone marrow transplantation is the last a glimmer of hope.But from transplantation and two weeks time,Emily's condition and the recurrence.Due to the condition of relief time too short,She can't accept a bone marrow transplant surgery.After two months,The doctor announced Emily's dying.

　　一次又一次的打击并没有让怀特黑德一家放弃。他们关注和搜集一切和急性淋巴细胞白血病相关的信息。当他们看到宾夕法尼亚大学和费城儿童医院的研究项目需要临床实验对象的消息，便立刻决定加入。埃米莉回忆当时的情形说：“这是实验性的治疗，但是爸爸、妈妈说我们该尝试些新的办法来治疗我的病。”

Again and again blow and didn't want to let the whitehead a give up.They concern and collect all and acute lymphocytic leukemia relevant information.When they saw the university of Pennsylvania and the children's hospital of Philadelphia research projects need to clinical subjects news,Immediately decided to join.Emily recall situation said:"This is the experimental treatment,But dad/Mom says we should try some new ways to treat my disease."

　　这种实验性疗法听起来有些“以毒攻毒”——利用艾滋病病毒来治疗白血病。来自琼团队的中国华侨科学家赵阳兵告诉《中国青年报》，早在2003年时，琼博士就开始进行这一开创性实验。此前，他曾试验用改造过的T淋巴细胞(简称T细胞)治疗艾滋病，取得了一些成果。这次，他反过来用艾滋病病毒改造T细胞治疗白血病。

The experimental treatment sounded"Set a thief to catch a thief"- using the AIDS virus to treat leukemia.From Joan team of Chinese overseas Chinese scientists ZhaoYangBing tell[The China youth daily],In the early 2003 s,Joan doctor started to carry on the ground-breaking experiment.after,He had test modified T lymphocyte(Referred to as T cells)A cure for AIDS,Made some achievements.the,He in turn with the AIDS virus transformation T cells to treat leukemia.

　　T细胞是人体自身免疫系统的重要部分。但是对于癌症病人，T细胞无法有效地自动识别和杀死癌细胞。但如果将改造过的、失去致病性的艾滋病病毒转入T细胞上，它就具备了识别和杀死癌细胞的能力。

T cell is human body itself an important part of the immune system.But for cancer patients,T cell cannot effectively automatic identification and kill cancer cells.But if will be modified/Lose of the pathogenicity of the AIDS virus into the T cells,It has the ability to identify and kill cancer cells.

　　之所以选择艾滋病病毒，是因为目前常用的，能够把基因有效稳定的转入T淋巴细胞的载体只有以艾滋病病毒为基础的慢病毒载体和逆转录病毒载体两种。这种艾滋病病毒载体能够达到高效转导，并且可以转导不分裂细胞。

Chose the AIDS virus,Because at present commonly used,The gene can effective stable into T lymphocyte carrier only to the AIDS virus based slow virus carrier and retrovirus vector two.The AIDS virus carrier can achieve efficient transduction,And can be transduction not splinter cell.

　　埃米莉只是12名接受这种疗法的晚期白血病患者中的一名。美国其他医疗中心也正在尝试类似的疗法，包括美国国家癌症研究所和纪念斯隆-凯特琳癌症中心。

Emily just 12 accept the treatment of terminal leukemia patients in a.The United States other medical center is also trying to similar therapy,Including the national cancer institute and memorial Sloan - caitlin cancer center.

　　给原本无法识别癌细胞的人体T细胞安上“瞄准器”和“子弹”，使得人体自身的免疫系统具备识别和杀死癌细胞的能力

To the original can't identify cancer cells of human T cells to install"sight"and"The bullet",Makes the body's own immune system has the ability to identify and kill cancer cells

　　赵阳兵是T细胞工程实验室的负责人。他曾在美国国立癌症研究所，在美国肿瘤免疫学泰斗级人物史蒂芬·罗森伯格手下工作。

ZhaoYangBing is T cell engineering in charge of the laboratory.He was in the U.S. national cancer institute,In the United States tumor immunology masters level character Steven rosenberg hand work.

　　他对《中国青年报》解释说，这一复杂的过程，就好比给原本无法识别癌细胞的人体T细胞安上了“瞄准器”和“子弹”，使得人体自身的免疫系统具备识别和杀死癌细胞的能力。艾滋病病毒的作用，就是装载“瞄准器”和“子弹”的卡槽。

he[The China youth daily]explained,The complicated process,Just like was unable to identify cancer cells of human T cells had"sight"and"The bullet",Makes the body's own immune system has the ability to identify and kill cancer cells.The role of the AIDS virus,Is loading"sight"and"The bullet"Card slot.

　　重新注入进人体的T细胞会在人体内大量增殖，一经刺激会产生记忆T细胞，从而形成长久的免疫。对那些在接受治疗后病情持久缓解的患者来说，改良的T细胞会长期留存在血液里，尽管它们后来的数量会少于抗击癌症时的数量。一些患者已携带这些细胞长达数年。

To inject into human T cells in the human body a lot of proliferation,Once stimulus will produce memory T cells,Thus forming long-term immunity.For those with treatment for patients with illness lasting ease,Improved T cells can long-term retention in the blood,Although they later quantity will be less than the amount of the fight against cancer.Some patients have to carry these cells for several years.

　　一位科学家解释说：“这些T细胞是活着的药片。对于药片，你服下之后就会从你的体内排出，你不得不再服一片。”

A scientist explained:"These T cells are alive tablets.For tablets,After you take from your body discharge,You can not no longer take one tablet."

　　2012年4月，埃米莉开始了治疗。为了纪念自己的新生活，这个牙齿不太整齐的小孩还为自己起了个昵称“埃玛”。她剪短了棕色头发，由于不喜欢刘海，理发时还要求不留刘海。

In April 2012,Emily began treatment.In order to commemorate his new life,The teeth don't tidy child for yourself up a nickname"Emma".She cut short brown hair,Because do not like bang,When hair also requires not bang.

　　但这种疗法差点要了她的命。汤姆告诉《中国青年报》，在注射T细胞的几天后，女儿发起了高烧，血压也一度下降，被转入了重症监护室。医院曾在4月24日晚上让他们做好最坏的准备——孩子只有千分之一的可能性脱离危险。

But this kind of therapy almost to her life.Tom told[The China youth daily],In a few days after injection of T cells,Daughter launched a high fever,Blood pressure was down,Be moved to the intensive medicine.The hospital had on April 24th evening let them to prepare for the worst, the possibility of only one over one thousand children out of danger.

　　对埃米莉的血液样本进行分析后，科学家们松了口气，她的反应不是感染，而是T细胞的威力。赵阳兵解释说，这种异常反应是T细胞杀死癌细胞的过程中释放出大量的细胞因子造成的。当时，他们发现病人的体内有一种叫做白介素6的细胞因子含量特别高，在注射了抗白介素6抗体后，埃米莉的体温很快恢复了正常。

In Emily's blood sample analysis,Scientists breathed a collective sigh of relief,Her reaction is not infected,But the power of T cells.ZhaoYangBing explained,This kind of abnormal reaction is T cell kill cancer cells in the process of the release of a large number of cell factors cause.At that time,They found that the patient's body has a called interleukin 6 cell factor was particularly high,In the given resistance of interleukin 6 after antibody,Emily temperature quickly returned to normal.

　　她的身体状况开始渐入佳境。接受治疗一个多月，她血液样本中的癌细胞数量就大大减少。这个喜欢粉色和紫色的女孩开始四处走动，还能和小狗露西玩上几个小时。

Her health started up-and-up.Treatment for more than a month,Her blood sample number of cancer cells are greatly reduced.This like pink and purple girl began to walk around,Can also and the puppy Lucy play on a few hours.

　　到了6月份，埃米莉体内的癌细胞彻底消失不见了。目前，她只需每个月回医院进行一次常规检查。

In June,Emily cancer cells in the body completely disappear.At present,She just every month back to the hospital for a routine check.

　　感谢你们一直在我生病时陪伴着我，等到你们生病的时候也让我陪伴你们吧

Thank you for always when I was ill with me,Wait until you are sick also let me accompany you it

　　埃米莉的成功案例让医学界极为振奋。3名在宾夕法尼亚大学接受治疗的慢性白血病成年患者也完全缓解，不再有任何疾病症状。戴维·波特博士说，他们中的两人已经在两年多的时间里保持了健康。4名成年患者的病情有所好转，但并未完全缓解；另有一名成年患者近期才接受治疗，其疗效有待评估。一名儿童患者有所好转，但随后旧病复发。

Emily's successful cases for the medical profession is very exciting.Three in the university of Pennsylvania for treatment of chronic leukemia adult patient also complete remission,There is no longer any signs of illness.David potter, "said Dr,Two of them already in more than two years of time to keep health.Four adult patients getting better,It did not ease;Otherwise an adult patients to treatment in the near future,Its curative effect evaluation needs to be.A child patients better,But then relapse.

　　琼博士说，通过基因工程制造T细胞的费用大约是2万美元一人(约合人民币13万元)——远远小于一次骨髓移植的费用。他说，扩大规模会进一步降低费用。但他又补充道，“我们的费用不包括任何利润率、设备折旧成本或其他的临床护理费用和其他的研究费用。”

Said Dr Joan,Through genetic engineering manufacture T cell costs about $20000 a person(130000 yuan)- far less than the cost of a bone marrow transplant.He said,Expansion will further reduce the cost.But he added,"Our fee does not include any profit margin/Equipment depreciation cost or other clinical nursing fees and other cost of the study."

　　世界制药巨头诺华公司已经购买了琼实验室的18项技术专利，致力于开发这种新型的治疗白血病的方法。这家公司斥资2000万美元(约合1.2亿元人民币)，在宾大校园建立了一所研究中心，来把这种疗法推向市场。

The world pharmaceutical giant novartis has purchased Joan laboratory and technology patent,Commitment to the development of this new method of treatment for leukemia.The company $20 million(About 120 million yuan RMB),At Penn campus established a research center,To put this kind of therapy to the market.

　　诺华肿瘤的总裁埃尔韦·奥普诺把这项研究称为“奇妙”，表示如果前期成果有效，这项研究可能会彻底改变白血病和其他血液类癌症的治疗方法。研究者称，同样的方法，即重新编码患者的免疫系统，也有可能最终被用于治疗乳腺癌和前列腺癌等肿瘤病。

Novartis tumor President el wei oliver PuNuo put the study called"wonderful",Said if the effective results,The study may be completely change leukemia and other blood kind of cancer treatment.The researchers say,The same method,Namely recoding patients' immune system,Also may eventually be used in the treatment of breast cancer and prostate cancer, etc.

　　但这一治疗方法还有待改进。赵阳兵对《中国青年报》坦言道，由于改良的T细胞中起主要作用的物质CD19，会把血液中的另一种免疫细胞B细胞杀死。这意味着，病人会因此产生体液免疫缺陷，需要终身定期注射免疫球蛋白来维持正常的免疫功能。

But the treatment also needs to be improved.ZhaoYangBing to[The China youth daily]Admitted to,Due to the improvement of T cell plays a principal role CD19 material,Will the blood of another kind of immune cell B cell kill.This means that,Patients will therefore produce humoral immune deficiency,Require lifelong periodic injections of immunoglobulin to maintain normal immune function.

　　对于科学家和患者来说，最理想的治疗方案是安全性最大化的方案。为了实现这个目标，赵阳兵和琼团队的50多名研究人员也在积极地努力。他们正在研究用RNA转染“瞄准镜”和“子弹”给T细胞。这位重庆第三军医大学的毕业生，2009年开始加入琼的实验室，专攻RNA转染T细胞的研究。

For scientists and for patients,The most ideal treatment scheme is maximum security solutions.In order to achieve this goal,ZhaoYangBing and Joan team more than fifty name researchers are also actively effort.They are studying with RNA transfection"sight"and"The bullet"To T cells.The chongqing third military medical university graduate,2009 start to join Joan's laboratory,Specialize in RNA transfection T cell research.

　　如今，汤姆告诉《中国青年报》，埃米莉已经在8月份重返了校园，继续二年级的课程，“她适应得很好，非常开心重新回到朋友们当中”。尽管她的成绩很好，每个月会读大约50本书，但她顽皮地坚称自己最喜爱的学科是午餐和休息。

now,Tom told[The China youth daily],Emily has to return to the campus in August,Continue to second-year course,"Her adjust to her very well,Very happy to return to the friends of".Although her performance is very good,Read about fifty books every month,But she naughtily insists his favorite subject is lunch and rest.

　　刚刚过去的万圣节，小姑娘特意给爸爸、妈妈买了一张印着大大的彩色“感谢”一词的贺卡。她用歪歪扭扭的笔迹在上面写道：“感谢你们一直在我生病时陪伴着我，等到你们生病的时候也让我陪伴你们吧！”(实习生 张莹）

Just the past Halloween,The little girl have to dad/My mother bought a big color printing"thank"A word of greeting CARDS.She crooked handwriting wrote on it:"Thank you for always when I was ill with me,Wait until you are sick also let me accompany you it!"(Interns ZhangYing)