中科院研究人员揭示细胞凋亡调控新奥秘 Chinese academy of sciences researchers reveals apoptotic new mystery

　　人体内细胞凋亡调控过程的紊乱与许多疾病的发生密切相关，中国科学院研究人员一项研究揭示了细胞凋亡调控的新奥秘，最新一期国际权威学术期刊《细胞》杂志发表了相关研究论文。

The human body cell apoptosis regulation process disorder and many disease closely related,Chinese academy of sciences, the researchers a study reveals the apoptotic new mystery,The latest issue of international authoritative academic journal[cell]Magazine published related research papers.

　　由中国科学院上海生物化学与细胞生物学研究所林安宁团队进行的这项研究，发现在调控细胞凋亡过程的“细胞信号网络”中，一个关键元素“蛋白激酶IKK”具有一项新的功能。

From the Chinese academy of sciences and Shanghai institute of biochemistry and cell biology LinAnNing team to conduct the research,Found in regulation of cell apoptosis process"Cell signaling network"in,A key element"Protein kinase IKK"Has a new function.

　　自从1997年“蛋白激酶IKK”被克隆以来，科学界一个经典的理论是：“蛋白激酶IKK”主要是通过激活细胞存活因子“NF-kB”来抑制细胞凋亡。许多制药公司也都是根据这一理论开发药物。

Since 1997"Protein kinase IKK"Since cloned,The scientific community a classical theory is:"Protein kinase IKK"Mainly through the activation cell survival factor"NF - kB"To inhibit apoptosis.Many pharmaceutical companies are also based on the theory of drug development.

　　林安宁研究团队发现，“蛋白激酶IKK”除了需要激活细胞存活因子“NF-kB”之外，还需要抑制促凋亡因子“BAD”，以抑制细胞凋亡。研究人员在小鼠实验中证实了这一发现。

LinAnNing research team found,"Protein kinase IKK"In addition to need to activate cell survival factor"NF - kB"outside,Still need to inhibit apoptosis stimulating factor"bad",To inhibit apoptosis.The researchers demonstrated in mice that the discovery.

　　最新一期国际权威学术期刊《细胞》杂志发表了相关研究论文。“蛋白激酶IKK”的发现人之一、美国科学院院士、美国加州大学圣地亚哥分校教授迈克尔高度评价了这项研究成果。

The latest issue of international authoritative academic journal[cell]Magazine published related research papers."Protein kinase IKK"Found of one of/American academy of sciences/The university of California, San Diego, professor Michael think highly of the research results.

　　根据这一理论，研究人员今后可从调控细胞存活因子“NF-kB”和促凋亡因子“BAD”两条通路，研发肿瘤等重大疾病的治疗手段，为将来开发特异性药物靶点、减少副作用提供了线索。 (张建松 曹蕾)

According to this theory,Researchers from the future control cell survival factor"NF - kB"And promote apoptosis factor"bad"Two pathways,R&d tumor major disease treatments,For the future development of specific drug targets/Reducing side effects provides clues. (ZhangJianSong CaoLei)