与人同源基因达到87% 斑马鱼成实验“明星” And people homologous gene 87% zebra fish into the experiment"star"

　　美丽发光的斑马鱼，正为生命科学的研究立下汗马功劳——11月9日，南京大学模式动物研究所在10周岁生日之际向公众揭开了神奇面纱。

Beautiful luminous zebra fish,Positive for life science research in a - November 9,,Nanjing university model animal research is 10 years old birthday to public revealed magic veil.

　　记者在温暖的实验室里看到，一群有着暗蓝与银色纵条纹的斑马鱼在许多鱼缸中不停游动。由于和人类基因有着高度同源性，它们成为近些年生物实验界的“红人”。

Reporter in the warm lab to see,A group of has a dark blue and silver longitudinal stripes zebrafish in many fish tank keep travelling.Because human genes and highly homology,They become biological experiment field in recent years"reds".

　　“3万个基因中有87%与人类同源，这意味着斑马鱼的实验结果在大多数情况下适用于人体。”实验室工作人员李奎告诉记者，这种鱼很好养，不到30平方米的房间能养几万条；而且每周产卵数量多，可做多种基因变异标本。“更重要的是，斑马鱼的胚胎通体透明，这在脊椎动物中是独一无二的——可以在光镜下直接观察胚胎的变化。”

"30000 genes in 87% and human homologous,This means that the zebrafish experimental results in most cases is applicable to the human body."Lab workers LiKui told reporters,This kind of fish is very good to raise,Less than 30 square meters of the room can raise article tens;A week number and laying eggs,To do a variety of genetic variation specimen."More important is,Zebrafish embryos translucent,This in vertebrate animals is unique - can be directly observed in the pathologic changes of embryos."

　　斑马鱼与同为脊椎动物的小鼠相比，还有一个极大的优越性：胚胎在体外发育，科研人员能在显微镜下直视并控制斑马鱼受精卵发育成为小鱼的全过程。这使得斑马鱼成为研究人类疾病发生机理的优良模式动物。

Zebra fish with for vertebrate than mice,There is also a great advantage:Embryo in vitro development,Scientific research personnel under the microscope can look straight and control zebrafish zygote become the whole process of small fish.This makes the zebrafish the the study of human disease mechanism of good model animals.

　　李奎说，通过对斑马鱼进行大规模化学诱变，已经可以模拟多种影响人类健康的重大疾病，比如人类贫血、耳聋、视网膜变性、肌无力症、恶性肿瘤和阿尔茨海默病等。“通过对斑马鱼卵的基因敲出、敲入，来锁定致病基因，达到攻克疾病的目的。”(记者 杨频萍)

LiKui said,Through the zebra fish on a large scale chemical mutagenesis,Have can simulate many kinds of the health effects of major disease,Such as the human anemia/deafness/Retinal degeneration/Muscle weakness syndrome/Malignant tumors and alzheimer's disease, etc."Through to the roe gene knock out/knock-in,To lock pathogenic gene,To achieve the purpose of conquer disease."(Reporter YangPin ping)