2012年8月，《美国临床营养学杂志》网站发表论文《黄金大米中的β-胡萝卜素与油胶囊中的β-胡萝卜素对儿童补充维生素A同样有效》。该论文的主要作者为美国塔夫茨大学汤光文、湖南省疾病预防控制中心胡余明、中国疾病预防控制中心营养与食品安全所荫士安和浙江省医学科学院王茵。

In August 2012,[The American journal of clinical nutrition]Website published[Golden rice of beta carotene and oil capsule of beta carotene on children supplement vitamin A also effective].This paper mainly the author is American tufts ShangGuangWen/Hunan centers for disease control and prevention YuMing hu/China's centers for disease control and prevention nutrition and food security shadow and Ann and zhejiang academy of medical sciences WangYin.

　　论文称，2008年，湖南80名6-8岁的小学生进行试验摄入“黄金大米”。该消息经环境组织披露后，引发公众广泛关注。

The paper says,In 2008,,Hunan 80 6-8 years of primary school children test intake"Golden rice".The news by environmental groups revealed,Cause the public attention.

黄金大米儿童试食事件还原 Golden rice children try food event reduction

　　“黄金大米”课题组主要成员

"Golden rice"The main members of the group

　　美国塔夫茨大学 汤光文

The United States ShangGuangWen at tufts university

　　湖南省疾病预防控制中心 胡余明

Hunan centers for disease control and prevention YuMing hu

　　中国疾病预防控制中心营养与食品安全所 荫士安

China's centers for disease control and prevention nutrition and food security, and the shadow

　　浙江省医学科学院 王茵

Zhejiang academy of medical sciences WangYin

　　1

1

　　2008年5月22日，课题组召开学生家长和监护人知情通报会，但没有向受试者家长和监护人说明试验将使用转基因的“黄金大米”。

May 22, 2008,Held his parents and guardians informed sessions,But no parents and guardians to subjects that test will use genetically modified"Golden rice".

　　2

2

　　“黄金大米”米饭系由汤光文在美国进行烹调后，未按规定向国内相关机构申报，于2008年5月29日携带入境。

"Golden rice"Rice is the ShangGuangWen in the United States after cooking,Not according to stipulations related domestic institutions to declare,In on May 29, 2008 carry entry.

　　3

3

　　6月2日午餐时，汤光文等人将加热的“黄金大米”米饭与白米饭混合搅拌后，分发给受试儿童食用。

June 2 at lunch,ShangGuangWen etc will be heated"Golden rice"Rice and rice hybrid mixed,Distributed to the tested children eat.

　　4

4

　　2008年6月2日，塔夫茨大学伦理审查委员会通过了对NIH项目中文版知情同意书的伦理审批，此前汤光文已在衡南县开始了试验。

June 2, 2008,Tufts ethical review board through the Nih project Chinese informed consent ethical approval,After ShangGuangWen has set up a file in the HengNaXian started test.

　　塔夫茨大学于2008年批准的该研究知情同意书中未提及试验材料是“转基因水稻”。

Tufts in 2008 approved the study informed consent is not mentioned in the test material"Transgenic rice".

　　5

5

　　2008年项目现场工作转到湖南后，王茵根据荫士安提供的材料，利用职务之便，私自加盖公章以浙江省医科院的名义向汤光文出具了英文版“2003年的伦理审查结果仍然有效”的证明。

In 2008, the site of the project work after turn to hunan,WangYin according to the shadow and the materials supplied by the Ann,And take advantage of their positions,Secretly build official seal YiKeYuan in zhejiang province in the name of the ShangGuangWen issue to the English version"2003 years of ethical review results are still effective"proof.

【缘起】 [origin]

十年前黄金大米相关试验立项 Ten years ago the golden rice related test project

　　今年8月，“黄金大米”事件引起卫生部和浙江省、湖南省有关方面高度重视，责成中国疾病预防控制中心、浙江省医学科学院和湖南省疾病预防控制中心联合对论文中涉及的有关问题进行了深入调查。

August,"Golden rice"Events caused by the ministry of health and zhejiang province/The attaches great importance to hunan province,Instruct Chinese centers for disease control and prevention/Zhejiang academy of medical sciences and hunan provincial centers for disease control and prevention of the thesis involves joint problems concerning the further investigation.

　　经调查，汤光文主持的“儿童植物类胡萝卜素维生素A当量研究”项目于2002年12月由美国国立卫生研究院（NIH）糖尿病消化道和肾病研究所批准，荫士安是该项目申请的成员之一。项目内容是研究菠菜、金水稻（俗称“黄金大米”）和β—胡萝卜素胶囊中的类胡萝卜素在儿童体内的吸收和转化成维生素A的效率，探索预防儿童维生素A缺乏症的途径。项目执行期为2002年2月至2007年2月，后延长至2009年8月。

After investigation,ShangGuangWen hosted"Children's plant carotenoids vitamin A equivalent research"Project in December 2002 by the United States national institutes of health(Nih)Diabetes digestive and kidney disease research institute approval,Shadow and Ann is the project application of one of the members.Content of the project is the study of spinach/Golden rice(Commonly known as"Golden rice")And beta - carotene capsule of carotenoids in children with absorption and converted into vitamin A efficiency,Explore prevent children from vitamin A deficiency of the way.Project execution for February 2002 to February 2007,After extended to August 2009.

　　2003年9月，荫士安以课题中国部分项目负责人的身份，与浙江省医科院签订了美国NIH课题合作协议书。塔夫茨大学于2004年8月与浙江省医科院签订合作研究协议备忘录，合作项目负责人是汤光文，中方负责人是荫士安和王茵。2004年10月浙江省医科院聘荫士安为客座研究员。

In September 2003,Shadow and Ann to subject China part of the project of the person in charge of the identity,And YiKeYuan zhejiang province signed a cooperation agreement the Nih subject.Tufts in August 2004 and zhejiang province signed memorandum of agreement YiKeYuan cooperative research,Cooperation is ShangGuangWen project leader,China is in the shadow of the Ann and WangYin.In October 2004, zhejiang province YiKeYuan wanted shadow and for visiting researcher.

【设点】 [second-hand]

签协议未告知衡南用黄金大米 Sign the agreement did not inform HengNaYong golden rice

　　2008年，该项目被转移至湖南省衡阳市衡南县现场，与荫士安在该地开展的国内项目“植物中类胡萝卜素在儿童体内转化成为维生素A的效率研究”合并进行。

In 2008,,The project has been transferred to the hunan hengyang HengNaXian field,And the shadow and Ann in the development of the domestic project"Plants carotenoids in children's body into vitamin A efficiency research"Combination on.

　　为开展国内的研究项目，中国疾控中心营养食品所与湖南省疾控中心签订了“植物中类胡萝卜素在儿童体内转化成为维生素A的效率研究”的课题合作协议书。

For the development of the domestic research project,The Chinese CDC nutrition food and hunan province CDC signed"Plants carotenoids in children's body into vitamin A efficiency research"Project cooperation agreement.

　　随后，浙江省医科院与湖南省衡南县疾控中心也签订了该项目现场试验合作协议书，但未明确告知实验将使用转基因大米或“黄金大米”，现场设在江口镇中心小学。

then,Zhejiang YiKeYuan with hunan HengNaXian CDC also signed the project site test cooperation agreement,But not told the experiment will use genetically modified rice or"Golden rice",Site is located in the JiangKouZhen center primary school.

【试验】 [test]

隐瞒试验仅给家长知情书最后页 Hide test only to give parents informed book the last page

　　2008年5月20日至6月23日，含“黄金大米”实验组的试验在湖南省衡南县江口镇中心小学实施。试验对象为80名儿童，随机分为3组，其中1组25名儿童于6月2日随午餐每人食用了60克“黄金大米”米饭，其余时间和其他组儿童均食用当地采购的食品。

In May 2008, twenty days to June 23,,including"Golden rice"The experimental test in hunan province HengNaXian JiangKouZhen center primary school implementation.Test object for 80 children,Randomly divided into three groups,One group of 25 children in June 2, each with lunch eat the sixty grams"Golden rice"rice,The rest of the time and other groups of children are eating local purchase of food.

　　“黄金大米”米饭系由汤光文在美国进行烹调后，未按规定向国内相关机构申报，于2008年5月29日携带入境。6月2日午餐时，汤光文等人将加热的“黄金大米”米饭与白米饭混合搅拌后，分发给受试儿童食用。

"Golden rice"Rice is the ShangGuangWen in the United States after cooking,Not according to stipulations related domestic institutions to declare,In on May 29, 2008 carry entry.June 2 at lunch,ShangGuangWen etc will be heated"Golden rice"Rice and rice hybrid mixed,Distributed to the tested children eat.

　　2008年5月22日，课题组召开学生家长和监护人知情通报会，但没有向受试者家长和监护人说明试验将使用转基因的“黄金大米”。现场未发放完整的知情同意书，仅发放了知情同意书的最后一页，学生家长或监护人该页上签了字，而该页上没有提及“黄金大米”，更未告知食用的是“转基因水稻”。

May 22, 2008,Held his parents and guardians informed sessions,But no parents and guardians to subjects that test will use genetically modified"Golden rice".The issue is not complete informed consent,Only released the last page of the informed consent,Students' parents or guardian signed page,And this page did not mention"Golden rice",The more did not inform food is"Transgenic rice".

【审批】 [Examination and approval]

私刻章以“浙江医科院”名义开证明 Private seals to"Zhejiang YiKeYuan"Name a certificate

　　2008年6月2日，塔夫茨大学伦理审查委员会通过了对NIH项目中文版知情同意书的伦理审批，而项目负责人未按规定，于5月22日提前开展了受试对象知情同意工作。塔夫茨大学于2008年批准的该研究知情同意书中未提及试验材料是“转基因水稻”，只是称为“黄金大米”。该大学伦理审查委员会在2003年至2006年间批准的该研究知情同意书中均有“黄金大米”是“转基因水稻”的描述。

June 2, 2008,Tufts ethical review board through the Nih project Chinese informed consent ethical approval,Project leader and not according to stipulations,On May 22, carried out in advance of the tested object informed consent work.Tufts in 2008 approved the study informed consent is not mentioned in the test material"Transgenic rice",Just called"Golden rice".The university ethics committee in 2003 to 2006 approved the study of informed consent are"Golden rice"is"Transgenic rice"description.

　　2003年11月，浙江省医科院伦理审查委员会通过了美国NIH项目的伦理审查。2008年项目现场工作转到湖南后，项目负责人未按规定再次申请伦理审查，王茵根据荫士安提供的材料，利用职务之便，私自加盖公章以浙江省医科院的名义向汤光文出具了英文版“2003年的伦理审查结果仍然有效”的证明。

In November 2003,Zhejiang YiKeYuan ethical review board through the Nih project ethical review.In 2008, the site of the project work after turn to hunan,The project not according to stipulations for ethical review again,WangYin according to the shadow and the materials supplied by the Ann,And take advantage of their positions,Secretly build official seal YiKeYuan in zhejiang province in the name of the ShangGuangWen issue to the English version"2003 years of ethical review results are still effective"proof.

　　【追查】

[trace]

　　未通过伦理审批已开始试验

Not through the ethical approval has started to test

　　项目在实施时，汤光文、荫士安和王茵作为项目负责人未在现场履行告知义务，在试验期间始终没有告知当地主管部门和项目承担单位开展的是“黄金大米”试验；在与学生家长签署知情同意书时故意使用“富含类胡萝卜素的大米”这一表述，刻意隐瞒了使用“黄金大米”的事实。

The project implementation,ShangGuangWen/Shadow and Ann and WangYin as project leader at the scene did not inform obligation to perform,In the test period has not told the local administrative departments and units to carry out projects is"Golden rice"test;In with the parents of the students signed informed consent intentionally use"Rich in carotenoids rice"This statement,Try to disguise the use"Golden rice"fact.

　　根据塔夫茨大学有关规定，单一试验项目的伦理审查应每年重审，项目内容如有变化应重新进行审查。汤光文于2008年在伦理审查重审未完成前，即在衡南县开始了试验。美国塔夫茨大学也正在对试验涉及违反伦理道德的问题开展调查。

According to the relevant provisions of the tufts,A single test project ethical review shall review each year,Content of the project such as have change should be to review.ShangGuangWen in 2008 in ethical review review before the unfinished,That is HengNaXian started test.The United States tufts is also the test involves a breach of ethics problem investigation.

　　本版稿件（除署名外）据中国疾病预防控制中心官网

This manuscript(In addition to the signature)According to China's centers for disease control and prevention's official website